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Intermittent Exposure to Chlorpyrifos Differentially Impacts Neuroreflex Control of Cardiorespiratory Function in Rats

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Intermittent Exposure to Chlorpyrifos Differentially Impacts Neuroreflex Control of Cardiorespiratory Function in Rats. / Batista, Thatiany Jardim; Minassa, Vítor Sampaio; Aitken, Andrew Vieira; Jara, Bianca Teixeira; Felippe, Igor Simões Assunção; Beijamini, Vanessa; Paton, Julian Francis Richmond; dos Santos, Leonardo; Sampaio, Karla Nívea.

In: Cardiovascular Toxicology, Vol. 19, No. 6, 01.12.2019, p. 548-564.

Research output: Contribution to journalArticle

Harvard

Batista, TJ, Minassa, VS, Aitken, AV, Jara, BT, Felippe, ISA, Beijamini, V, Paton, JFR, dos Santos, L & Sampaio, KN 2019, 'Intermittent Exposure to Chlorpyrifos Differentially Impacts Neuroreflex Control of Cardiorespiratory Function in Rats', Cardiovascular Toxicology, vol. 19, no. 6, pp. 548-564. https://doi.org/10.1007/s12012-019-09528-7

APA

Batista, T. J., Minassa, V. S., Aitken, A. V., Jara, B. T., Felippe, I. S. A., Beijamini, V., ... Sampaio, K. N. (2019). Intermittent Exposure to Chlorpyrifos Differentially Impacts Neuroreflex Control of Cardiorespiratory Function in Rats. Cardiovascular Toxicology, 19(6), 548-564. https://doi.org/10.1007/s12012-019-09528-7

Vancouver

Batista TJ, Minassa VS, Aitken AV, Jara BT, Felippe ISA, Beijamini V et al. Intermittent Exposure to Chlorpyrifos Differentially Impacts Neuroreflex Control of Cardiorespiratory Function in Rats. Cardiovascular Toxicology. 2019 Dec 1;19(6):548-564. https://doi.org/10.1007/s12012-019-09528-7

Author

Batista, Thatiany Jardim ; Minassa, Vítor Sampaio ; Aitken, Andrew Vieira ; Jara, Bianca Teixeira ; Felippe, Igor Simões Assunção ; Beijamini, Vanessa ; Paton, Julian Francis Richmond ; dos Santos, Leonardo ; Sampaio, Karla Nívea. / Intermittent Exposure to Chlorpyrifos Differentially Impacts Neuroreflex Control of Cardiorespiratory Function in Rats. In: Cardiovascular Toxicology. 2019 ; Vol. 19, No. 6. pp. 548-564.

Bibtex

@article{a06548b385d14f5abe0c4c18275d0900,
title = "Intermittent Exposure to Chlorpyrifos Differentially Impacts Neuroreflex Control of Cardiorespiratory Function in Rats",
abstract = "Previous studies showed that chlorpyrifos (CPF) acute exposure impaired cardiorespiratory reflexes. Evidence also indicates that continuous exposure to organophosphorus compounds impairs cardiovascular function. However, the effect of intermittent exposure to CPF, as may be experienced in the real world, on tonic and reflex cardiorespiratory function remains unexplored. Wistar rats were injected with saline or CPF for 4 weeks (3 times/week) or 12 weeks (once/week) at the doses of 7 mg/kg and 10 mg/kg. After exposure, blood pressure (BP), heart rate (HR), respiratory rate (fR), tidal volume (VT), and minute volume (VE) were recorded. Systolic BP and pulse interval (PI) variability, HR spectrum, spontaneous baroreflex and chemoreflex function were also evaluated. Plasma butyrylcholinesterase and brainstem acetylcholinesterase activities were quantified. Enzymatic activity of the CPF animals was reduced after both treatment periods. Baseline BP, HR, and fR, as well as systolic BP and PI variability indices, did not change, after CPF treatment. VT and VE were elevated in CPF animals. CPF exposure increased the very low-frequency component of the HR spectrum. Baroreflex gain was reduced after CPF 4-week exposure. Chemoreflex bradycardia was reduced in the CPF-treated rats. These data show that intermittent exposure to CPF impairs cardiorespiratory function in rats. These results may have important clinical implications for workers seasonally exposed to these compounds.",
keywords = "Acetylcholinesterase, Baroreflex, Butyrylcholinesterase, Cardiovascular variability, Chemoreflex, Chlorpyrifos",
author = "Batista, {Thatiany Jardim} and Minassa, {V{\'i}tor Sampaio} and Aitken, {Andrew Vieira} and Jara, {Bianca Teixeira} and Felippe, {Igor Sim{\~o}es Assun{\cc}{\~a}o} and Vanessa Beijamini and Paton, {Julian Francis Richmond} and {dos Santos}, Leonardo and Sampaio, {Karla N{\'i}vea}",
note = "The acceptance date for this record is provisional and based upon the month of publication for the article.",
year = "2019",
month = "12",
day = "1",
doi = "10.1007/s12012-019-09528-7",
language = "English",
volume = "19",
pages = "548--564",
journal = "Cardiovascular Toxicology",
issn = "1530-7905",
number = "6",

}

RIS - suitable for import to EndNote

TY - JOUR

T1 - Intermittent Exposure to Chlorpyrifos Differentially Impacts Neuroreflex Control of Cardiorespiratory Function in Rats

AU - Batista, Thatiany Jardim

AU - Minassa, Vítor Sampaio

AU - Aitken, Andrew Vieira

AU - Jara, Bianca Teixeira

AU - Felippe, Igor Simões Assunção

AU - Beijamini, Vanessa

AU - Paton, Julian Francis Richmond

AU - dos Santos, Leonardo

AU - Sampaio, Karla Nívea

N1 - The acceptance date for this record is provisional and based upon the month of publication for the article.

PY - 2019/12/1

Y1 - 2019/12/1

N2 - Previous studies showed that chlorpyrifos (CPF) acute exposure impaired cardiorespiratory reflexes. Evidence also indicates that continuous exposure to organophosphorus compounds impairs cardiovascular function. However, the effect of intermittent exposure to CPF, as may be experienced in the real world, on tonic and reflex cardiorespiratory function remains unexplored. Wistar rats were injected with saline or CPF for 4 weeks (3 times/week) or 12 weeks (once/week) at the doses of 7 mg/kg and 10 mg/kg. After exposure, blood pressure (BP), heart rate (HR), respiratory rate (fR), tidal volume (VT), and minute volume (VE) were recorded. Systolic BP and pulse interval (PI) variability, HR spectrum, spontaneous baroreflex and chemoreflex function were also evaluated. Plasma butyrylcholinesterase and brainstem acetylcholinesterase activities were quantified. Enzymatic activity of the CPF animals was reduced after both treatment periods. Baseline BP, HR, and fR, as well as systolic BP and PI variability indices, did not change, after CPF treatment. VT and VE were elevated in CPF animals. CPF exposure increased the very low-frequency component of the HR spectrum. Baroreflex gain was reduced after CPF 4-week exposure. Chemoreflex bradycardia was reduced in the CPF-treated rats. These data show that intermittent exposure to CPF impairs cardiorespiratory function in rats. These results may have important clinical implications for workers seasonally exposed to these compounds.

AB - Previous studies showed that chlorpyrifos (CPF) acute exposure impaired cardiorespiratory reflexes. Evidence also indicates that continuous exposure to organophosphorus compounds impairs cardiovascular function. However, the effect of intermittent exposure to CPF, as may be experienced in the real world, on tonic and reflex cardiorespiratory function remains unexplored. Wistar rats were injected with saline or CPF for 4 weeks (3 times/week) or 12 weeks (once/week) at the doses of 7 mg/kg and 10 mg/kg. After exposure, blood pressure (BP), heart rate (HR), respiratory rate (fR), tidal volume (VT), and minute volume (VE) were recorded. Systolic BP and pulse interval (PI) variability, HR spectrum, spontaneous baroreflex and chemoreflex function were also evaluated. Plasma butyrylcholinesterase and brainstem acetylcholinesterase activities were quantified. Enzymatic activity of the CPF animals was reduced after both treatment periods. Baseline BP, HR, and fR, as well as systolic BP and PI variability indices, did not change, after CPF treatment. VT and VE were elevated in CPF animals. CPF exposure increased the very low-frequency component of the HR spectrum. Baroreflex gain was reduced after CPF 4-week exposure. Chemoreflex bradycardia was reduced in the CPF-treated rats. These data show that intermittent exposure to CPF impairs cardiorespiratory function in rats. These results may have important clinical implications for workers seasonally exposed to these compounds.

KW - Acetylcholinesterase

KW - Baroreflex

KW - Butyrylcholinesterase

KW - Cardiovascular variability

KW - Chemoreflex

KW - Chlorpyrifos

UR - http://www.scopus.com/inward/record.url?scp=85066017119&partnerID=8YFLogxK

U2 - 10.1007/s12012-019-09528-7

DO - 10.1007/s12012-019-09528-7

M3 - Article

C2 - 31098944

AN - SCOPUS:85066017119

VL - 19

SP - 548

EP - 564

JO - Cardiovascular Toxicology

JF - Cardiovascular Toxicology

SN - 1530-7905

IS - 6

ER -