International comparison of trends in patients commencing renal replacement therapy by primary renal disease

Vianda S Stel, Ryan Awadhpersad, Maria Pippias, Manuel Ferrer-Alamar, Patrik Finne, Simon D Fraser, James G Heaf, Marc H Hemmelder, Alberto Martínez-Castelao, Johan de Meester, Runolfur Palsson, Friedrich C Prischl, Mårten Segelmark, Jamie P Traynor, Rafael Santamaria, Anna Varberg Reisaeter, Ziad A Massy, Kitty J Jager

Research output: Contribution to journalArticle (Academic Journal)peer-review

10 Citations (Scopus)


AIM: To examine international time trends in the incidence of renal replacement therapy (RRT) for end-stage renal disease (ESRD) by primary renal disease (PRD).

METHODS: Renal registries reporting on patients starting RRT per million population for ESRD by PRD from 2005 to 2014, were identified by internet search and literature review. The average annual percentage change (AAPC) with a 95% confidence interval (CI) of the time trends was computed using Joinpoint regression.

RESULTS: There was a significant decrease in the incidence of RRT for ESRD due to diabetes mellitus (DM) in Europe (AAPC = -0.9; 95%CI -1.3; -0.5) and to hypertension/renal vascular disease (HT/RVD) in Australia (AAPC = -1.8; 95%CI -3.3; -0.3), Canada (AAPC = -2.9; 95%CI -4.4; -1.5) and Europe (AAPC = -1.1; 95%CI -2.1; -0.0). A decrease or stabilization was observed for glomerulonephritis in all regions and for autosomal dominant polycystic kidney disease (ADPKD) in all regions except for Malaysia and the Republic of Korea. An increase of 5.2-16.3% was observed for DM, HT/RVD and ADPKD in Malaysia and the Republic of Korea.

CONCLUSION: Large international differences exist in the trends in incidence of RRT by primary renal disease. Mapping of these international trends is the first step in defining the causes and successful preventative measures of CKD.

Original languageEnglish
Pages (from-to)1064-1076
Number of pages13
Issue number10
Publication statusPublished - 1 Oct 2019

Bibliographical note

© 2018 Asian Pacific Society of Nephrology.


  • Adult
  • Aged
  • Diabetic Nephropathies/complications
  • Female
  • Global Health/trends
  • Glomerulonephritis/complications
  • Humans
  • Incidence
  • Kidney Failure, Chronic/epidemiology
  • Male
  • Middle Aged
  • Polycystic Kidney, Autosomal Dominant/complications
  • Preventive Health Services
  • Public Health/trends
  • Renal Replacement Therapy/methods
  • Risk Factors
  • Vascular Diseases/complications


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