TY - JOUR
T1 - International GWAS Consortium Identifies Novel Loci Associated with Blood Pressure in Children and Adolescents
AU - Parmar, Priyakumari Ganesh
AU - Taal, H Rob
AU - Timpson, Nicholas J
AU - Thiering, Elisabeth
AU - Lehtimäki, Terho
AU - Marinelli, Marcella
AU - Lind, Penelope A
AU - Howe, Laura D
AU - Verwoert, Germaine
AU - Aalto, Ville
AU - Uitterlinden, André G
AU - Briollais, Laurent
AU - Evans, David M
AU - Wright, Margaret J
AU - Newnham, John P
AU - Whitfield, John B
AU - Lyytikäinen, Leo-Pekka
AU - Rivadeneira, Fernando
AU - Boomsma, Dorret I
AU - Viikari, Jorma
AU - Gillman, Matthew W
AU - St Pourcain, Beate
AU - Hottenga, Jouke-Jan
AU - Montgomery, Grant W
AU - Hofman, Albert
AU - Kähönen, Mika
AU - Martin, Nicholas G
AU - Tobin, Martin D
AU - Raitakari, Olli
AU - Vioque, Jesus
AU - Jaddoe, Vincent W V
AU - Jarvelin, Marjo-Riitta
AU - Beilin, Lawrence J
AU - Heinrich, Joachim
AU - van Duijn, Cornelia M
AU - Pennell, Craig E
AU - Lawlor, Debbie A
AU - Palmer, Lyle J
AU - EArly Genetics and Lifecourse Epidemiology Consortium
PY - 2016/3/11
Y1 - 2016/3/11
N2 - BACKGROUND: -Our aim was to identify genetic variants associated with blood pressure (BP) in childhood and adolescence.METHODS AND RESULTS: -Genome-wide association study data from participating European ancestry cohorts of the EAGLE ( EA: rly G: enetics and L: ifecourse E: pidemiology) Consortium was meta-analysed across three 'epochs'; pre-puberty [4-7 years], puberty [8-12 years] and post-puberty [13-20 years]. Two novel loci were identified as having genome-wide associations with systolic blood pressure across specific age epochs; rs1563894 (ITGA11, located in active H3K27Ac mark and transcription factor CHiP and CpG methylation site) during pre-puberty (p = 2.86 × 10(-8)) and rs872256 during puberty (p = 8.67 × 10(-9)). Several SNP 'clusters' were also associated with childhood BP at p < 5 × 10(-3). Using a p-value threshold of < 5 × 10(-3) we found some overlap in variants across the different age epochs within our study, and between several SNPs in any of the three epochs and adult BP related SNPs.CONCLUSIONS: -Our results suggest that genetic determinants of blood pressure act from childhood, develop over the lifecourse, and show some evidence of age-specific effects.
AB - BACKGROUND: -Our aim was to identify genetic variants associated with blood pressure (BP) in childhood and adolescence.METHODS AND RESULTS: -Genome-wide association study data from participating European ancestry cohorts of the EAGLE ( EA: rly G: enetics and L: ifecourse E: pidemiology) Consortium was meta-analysed across three 'epochs'; pre-puberty [4-7 years], puberty [8-12 years] and post-puberty [13-20 years]. Two novel loci were identified as having genome-wide associations with systolic blood pressure across specific age epochs; rs1563894 (ITGA11, located in active H3K27Ac mark and transcription factor CHiP and CpG methylation site) during pre-puberty (p = 2.86 × 10(-8)) and rs872256 during puberty (p = 8.67 × 10(-9)). Several SNP 'clusters' were also associated with childhood BP at p < 5 × 10(-3). Using a p-value threshold of < 5 × 10(-3) we found some overlap in variants across the different age epochs within our study, and between several SNPs in any of the three epochs and adult BP related SNPs.CONCLUSIONS: -Our results suggest that genetic determinants of blood pressure act from childhood, develop over the lifecourse, and show some evidence of age-specific effects.
U2 - 10.1161/CIRCGENETICS.115.001190
DO - 10.1161/CIRCGENETICS.115.001190
M3 - Article (Academic Journal)
C2 - 26969751
JO - Circulation: Cardiovascular Genetics
JF - Circulation: Cardiovascular Genetics
SN - 1942-325X
ER -