International GWAS Consortium Identifies Novel Loci Associated with Blood Pressure in Children and Adolescents

Priyakumari Ganesh Parmar; H Rob Taal; Nicholas J Timpson; Elisabeth Thiering; Terho Lehtimäki; Marcella Marinelli; Penelope A Lind; Laura D Howe; Germaine Verwoert; Ville Aalto; André G Uitterlinden; Laurent Briollais; David M Evans; Margaret J Wright; John P Newnham; John B Whitfield; Leo-Pekka Lyytikäinen; Fernando Rivadeneira; Dorret I Boomsma; Jorma Viikari; Matthew W Gillman; Beate St Pourcain; Jouke-Jan Hottenga; Grant W Montgomery; Albert Hofman; Mika Kähönen; Nicholas G Martin; Martin D Tobin; Olli Raitakari; Jesus Vioque; Vincent W V Jaddoe; Marjo-Riitta Jarvelin; Lawrence J Beilin; Joachim Heinrich; Cornelia M van Duijn; Craig E Pennell; Debbie A Lawlor; Lyle J Palmer; EArly Genetics and Lifecourse Epidemiology Consortium

doi:10.1161/CIRCGENETICS.115.001190

International GWAS Consortium Identifies Novel Loci Associated with Blood Pressure in Children and Adolescents

Priyakumari Ganesh Parmar, H Rob Taal, Nicholas J Timpson, Elisabeth Thiering, Terho Lehtimäki, Marcella Marinelli, Penelope A Lind, Laura D Howe, Germaine Verwoert, Ville Aalto, André G Uitterlinden, Laurent Briollais, David M Evans, Margaret J Wright, John P Newnham, John B Whitfield, Leo-Pekka Lyytikäinen, Fernando Rivadeneira, Dorret I Boomsma, Jorma ViikariMatthew W Gillman, Beate St Pourcain, Jouke-Jan Hottenga, Grant W Montgomery, Albert Hofman, Mika Kähönen, Nicholas G Martin, Martin D Tobin, Olli Raitakari, Jesus Vioque, Vincent W V Jaddoe, Marjo-Riitta Jarvelin, Lawrence J Beilin, Joachim Heinrich, Cornelia M van Duijn, Craig E Pennell, Debbie A Lawlor, Lyle J Palmer, EArly Genetics and Lifecourse Epidemiology Consortium

Research output: Contribution to journal › Article (Academic Journal) › peer-review

34 Citations (Scopus)

Abstract

BACKGROUND: -Our aim was to identify genetic variants associated with blood pressure (BP) in childhood and adolescence.

METHODS AND RESULTS: -Genome-wide association study data from participating European ancestry cohorts of the EAGLE ( EA: rly G: enetics and L: ifecourse E: pidemiology) Consortium was meta-analysed across three 'epochs'; pre-puberty [4-7 years], puberty [8-12 years] and post-puberty [13-20 years]. Two novel loci were identified as having genome-wide associations with systolic blood pressure across specific age epochs; rs1563894 (ITGA11, located in active H3K27Ac mark and transcription factor CHiP and CpG methylation site) during pre-puberty (p = 2.86 × 10(-8)) and rs872256 during puberty (p = 8.67 × 10(-9)). Several SNP 'clusters' were also associated with childhood BP at p < 5 × 10(-3). Using a p-value threshold of < 5 × 10(-3) we found some overlap in variants across the different age epochs within our study, and between several SNPs in any of the three epochs and adult BP related SNPs.

CONCLUSIONS: -Our results suggest that genetic determinants of blood pressure act from childhood, develop over the lifecourse, and show some evidence of age-specific effects.

Original language	English
Journal	Circulation: Cardiovascular Genetics
DOIs	https://doi.org/10.1161/CIRCGENETICS.115.001190
Publication status	Published - 11 Mar 2016

Access to Document

10.1161/CIRCGENETICS.115.001190

Handle.net

Persistent link

Laura Howe Population Health Scientist Fellowship
Howe, L. D. (Principal Investigator)
1/09/15 → 31/12/22
Project: Research
MRC UoB UNITE Unit - programme 3
Timpson, N. J. (Principal Investigator) & Timpson, N. J. (Principal Investigator)
1/06/13 → 31/03/18
Project: Research
IEU Theme 3
Windmeijer, F. (Principal Investigator), Tilling, K. M. (Researcher) & Tilling, K. M. (Principal Investigator)
1/06/13 → 31/03/18
Project: Research

Cite this

Parmar, P. G., Taal, H. R., Timpson, N. J., Thiering, E., Lehtimäki, T., Marinelli, M., Lind, P. A., Howe, L. D., Verwoert, G., Aalto, V., Uitterlinden, A. G., Briollais, L., Evans, D. M., Wright, M. J., Newnham, J. P., Whitfield, J. B., Lyytikäinen, L.-P., Rivadeneira, F., Boomsma, D. I., ... EArly Genetics and Lifecourse Epidemiology Consortium (2016). International GWAS Consortium Identifies Novel Loci Associated with Blood Pressure in Children and Adolescents. Circulation: Cardiovascular Genetics. https://doi.org/10.1161/CIRCGENETICS.115.001190

@article{9dc8a98bf1e044c88ed7d7fdb8919a58,

title = "International GWAS Consortium Identifies Novel Loci Associated with Blood Pressure in Children and Adolescents",

abstract = "BACKGROUND: -Our aim was to identify genetic variants associated with blood pressure (BP) in childhood and adolescence.METHODS AND RESULTS: -Genome-wide association study data from participating European ancestry cohorts of the EAGLE ( EA: rly G: enetics and L: ifecourse E: pidemiology) Consortium was meta-analysed across three 'epochs'; pre-puberty [4-7 years], puberty [8-12 years] and post-puberty [13-20 years]. Two novel loci were identified as having genome-wide associations with systolic blood pressure across specific age epochs; rs1563894 (ITGA11, located in active H3K27Ac mark and transcription factor CHiP and CpG methylation site) during pre-puberty (p = 2.86 × 10(-8)) and rs872256 during puberty (p = 8.67 × 10(-9)). Several SNP 'clusters' were also associated with childhood BP at p < 5 × 10(-3). Using a p-value threshold of < 5 × 10(-3) we found some overlap in variants across the different age epochs within our study, and between several SNPs in any of the three epochs and adult BP related SNPs.CONCLUSIONS: -Our results suggest that genetic determinants of blood pressure act from childhood, develop over the lifecourse, and show some evidence of age-specific effects.",

author = "Parmar, {Priyakumari Ganesh} and Taal, {H Rob} and Timpson, {Nicholas J} and Elisabeth Thiering and Terho Lehtim{\"a}ki and Marcella Marinelli and Lind, {Penelope A} and Howe, {Laura D} and Germaine Verwoert and Ville Aalto and Uitterlinden, {Andr{\'e} G} and Laurent Briollais and Evans, {David M} and Wright, {Margaret J} and Newnham, {John P} and Whitfield, {John B} and Leo-Pekka Lyytik{\"a}inen and Fernando Rivadeneira and Boomsma, {Dorret I} and Jorma Viikari and Gillman, {Matthew W} and {St Pourcain}, Beate and Jouke-Jan Hottenga and Montgomery, {Grant W} and Albert Hofman and Mika K{\"a}h{\"o}nen and Martin, {Nicholas G} and Tobin, {Martin D} and Olli Raitakari and Jesus Vioque and Jaddoe, {Vincent W V} and Marjo-Riitta Jarvelin and Beilin, {Lawrence J} and Joachim Heinrich and {van Duijn}, {Cornelia M} and Pennell, {Craig E} and Lawlor, {Debbie A} and Palmer, {Lyle J} and {EArly Genetics and Lifecourse Epidemiology Consortium}",

year = "2016",

month = mar,

day = "11",

doi = "10.1161/CIRCGENETICS.115.001190",

language = "English",

journal = "Circulation: Cardiovascular Genetics",

issn = "1942-325X",

publisher = "Lippincott Williams and Wilkins",

}

Parmar, PG, Taal, HR, Timpson, NJ, Thiering, E, Lehtimäki, T, Marinelli, M, Lind, PA, Howe, LD, Verwoert, G, Aalto, V, Uitterlinden, AG, Briollais, L, Evans, DM, Wright, MJ, Newnham, JP, Whitfield, JB, Lyytikäinen, L-P, Rivadeneira, F, Boomsma, DI, Viikari, J, Gillman, MW, St Pourcain, B, Hottenga, J-J, Montgomery, GW, Hofman, A, Kähönen, M, Martin, NG, Tobin, MD, Raitakari, O, Vioque, J, Jaddoe, VWV, Jarvelin, M-R, Beilin, LJ, Heinrich, J, van Duijn, CM, Pennell, CE, Lawlor, DA, Palmer, LJ & EArly Genetics and Lifecourse Epidemiology Consortium 2016, 'International GWAS Consortium Identifies Novel Loci Associated with Blood Pressure in Children and Adolescents', Circulation: Cardiovascular Genetics. https://doi.org/10.1161/CIRCGENETICS.115.001190

TY - JOUR

T1 - International GWAS Consortium Identifies Novel Loci Associated with Blood Pressure in Children and Adolescents

AU - Parmar, Priyakumari Ganesh

AU - Taal, H Rob

AU - Timpson, Nicholas J

AU - Thiering, Elisabeth

AU - Lehtimäki, Terho

AU - Marinelli, Marcella

AU - Lind, Penelope A

AU - Howe, Laura D

AU - Verwoert, Germaine

AU - Aalto, Ville

AU - Uitterlinden, André G

AU - Briollais, Laurent

AU - Evans, David M

AU - Wright, Margaret J

AU - Newnham, John P

AU - Whitfield, John B

AU - Lyytikäinen, Leo-Pekka

AU - Rivadeneira, Fernando

AU - Boomsma, Dorret I

AU - Viikari, Jorma

AU - Gillman, Matthew W

AU - St Pourcain, Beate

AU - Hottenga, Jouke-Jan

AU - Montgomery, Grant W

AU - Hofman, Albert

AU - Kähönen, Mika

AU - Martin, Nicholas G

AU - Tobin, Martin D

AU - Raitakari, Olli

AU - Vioque, Jesus

AU - Jaddoe, Vincent W V

AU - Jarvelin, Marjo-Riitta

AU - Beilin, Lawrence J

AU - Heinrich, Joachim

AU - van Duijn, Cornelia M

AU - Pennell, Craig E

AU - Lawlor, Debbie A

AU - Palmer, Lyle J

AU - EArly Genetics and Lifecourse Epidemiology Consortium

PY - 2016/3/11

Y1 - 2016/3/11

N2 - BACKGROUND: -Our aim was to identify genetic variants associated with blood pressure (BP) in childhood and adolescence.METHODS AND RESULTS: -Genome-wide association study data from participating European ancestry cohorts of the EAGLE ( EA: rly G: enetics and L: ifecourse E: pidemiology) Consortium was meta-analysed across three 'epochs'; pre-puberty [4-7 years], puberty [8-12 years] and post-puberty [13-20 years]. Two novel loci were identified as having genome-wide associations with systolic blood pressure across specific age epochs; rs1563894 (ITGA11, located in active H3K27Ac mark and transcription factor CHiP and CpG methylation site) during pre-puberty (p = 2.86 × 10(-8)) and rs872256 during puberty (p = 8.67 × 10(-9)). Several SNP 'clusters' were also associated with childhood BP at p < 5 × 10(-3). Using a p-value threshold of < 5 × 10(-3) we found some overlap in variants across the different age epochs within our study, and between several SNPs in any of the three epochs and adult BP related SNPs.CONCLUSIONS: -Our results suggest that genetic determinants of blood pressure act from childhood, develop over the lifecourse, and show some evidence of age-specific effects.

AB - BACKGROUND: -Our aim was to identify genetic variants associated with blood pressure (BP) in childhood and adolescence.METHODS AND RESULTS: -Genome-wide association study data from participating European ancestry cohorts of the EAGLE ( EA: rly G: enetics and L: ifecourse E: pidemiology) Consortium was meta-analysed across three 'epochs'; pre-puberty [4-7 years], puberty [8-12 years] and post-puberty [13-20 years]. Two novel loci were identified as having genome-wide associations with systolic blood pressure across specific age epochs; rs1563894 (ITGA11, located in active H3K27Ac mark and transcription factor CHiP and CpG methylation site) during pre-puberty (p = 2.86 × 10(-8)) and rs872256 during puberty (p = 8.67 × 10(-9)). Several SNP 'clusters' were also associated with childhood BP at p < 5 × 10(-3). Using a p-value threshold of < 5 × 10(-3) we found some overlap in variants across the different age epochs within our study, and between several SNPs in any of the three epochs and adult BP related SNPs.CONCLUSIONS: -Our results suggest that genetic determinants of blood pressure act from childhood, develop over the lifecourse, and show some evidence of age-specific effects.

U2 - 10.1161/CIRCGENETICS.115.001190

DO - 10.1161/CIRCGENETICS.115.001190

M3 - Article (Academic Journal)

C2 - 26969751

SN - 1942-325X

JO - Circulation: Cardiovascular Genetics

JF - Circulation: Cardiovascular Genetics

ER -

International GWAS Consortium Identifies Novel Loci Associated with Blood Pressure in Children and Adolescents

Abstract

Access to Document

Handle.net

Fingerprint

Projects

Laura Howe Population Health Scientist Fellowship

MRC UoB UNITE Unit - programme 3

IEU Theme 3

Cite this