International Society of Nephrology First Consensus Guidance for Pre-Clinical Animal Studies in Translational Nephrology

Masaomi Nangaku*, Fergus J Caskey, Moin Saleem, A Richard Kitching, Peter Boor, Alessia Fornoni

*Corresponding author for this work

Research output: Contribution to journalReview article (Academic Journal)peer-review

13 Citations (Scopus)

Abstract

Pre-clinical tests in animal models are key steps in early drug development. Consequently, the International Society of Nephrology held a consensus meeting that connected experts in the global kidney community to provide guidance on optimal management of translational animal studies for the development of new drugs to treat kidney disease: “TRANSFORM; TRAnslational Nephrology Science FOR new Medications.” The meeting covered themes including: (1) selection of disease model; (2) pharmacokinetics; (3) interventions in late pre-clinical models; (4) choice of animal; (5) statistical power; (6) organoids and organ-on-a-chip models; and (7) reporting results. This is the first guidance on the optimal conduct of translational animal studies for the development of new drugs to treat kidney disease. These recommendations are designed to accelerate development of new drugs for efficacious treatment of kidney diseases, and to improve prognosis and the quality of life of patients with a variety of kidney diseases.
Original languageEnglish
Pages (from-to)36-45
Number of pages10
JournalKidney International
Volume104
Issue number1
Early online date28 Mar 2023
DOIs
Publication statusPublished - 1 Jul 2023

Bibliographical note

Publisher Copyright:
© 2023 International Society of Nephrology

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