International stroke genetics consortium recommendations for studies of genetics of stroke outcome and recovery.

Research output: Contribution to journalArticle (Academic Journal)peer-review

Abstract

Numerous biological mechanisms contribute to outcome after stroke, including brain injury, inflammation, and repair mechanisms. Clinical genetic studies have the potential to discover biological mechanisms affecting stroke recovery in humans and identify intervention targets. Large sample sizes are needed to detect commonly occurring genetic variations related to stroke brain injury and recovery. However, this usually requires combining data from multiple studies where consistent terminology, methodology, and data collection timelines are essential. Our group of expert stroke and rehabilitation clinicians and researchers with knowledge in genetics of stroke recovery here present recommendations for harmonizing phenotype data with focus on measures suitable for multicenter genetic studies of ischemic stroke brain injury and recovery. Our recommendations have been endorsed by the International Stroke Genetics Consortium.
Original languageEnglish
JournalInternational journal of stroke : official journal of the International Stroke Society
Early online date26 Apr 2021
DOIs
Publication statusPublished - 26 Apr 2021

Bibliographical note

Funding Information:
The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This work was supported by National Institute of Child Health and Human Development (K12HD093427); Lund University; National Institute of Neurological Disorders and Stroke (K23NS099487-01, R01-NS082285, R01-NS086905, U19-NS115388 and 5U10NS086606); National Institutes of Health (KL2TR003016, R01-NS085419, R01-NS100178, R01-NS105150, R01-NS114045, R21-NS106480, U24-NS107230, U24-NS107237 and U24-NS107222); Maestro Project and Ibiostroke project funded by Eranet-Neuron, ISCIII and FEDER; CaNVAS project funded by National Institutes of Health; Department of Biotechnology, Ministry of Science and Technology, India; Skåne University Hospital; Region Skåne; The Swedish Heart and Lung Foundation; and The Swedish Research Council (2018–02543 and 2019–01757); The Swedish Government (under the “Avtal om Läkarutbildning och Medicinsk Forskning, ALF”); Sparbanksstiftelsen Färs och Frosta; Freemason's Lodge of Instruction Eos, Lund; FWO Flanders (1841918N); US Department of Veteran Affairs, the American Heart Association (15GPSG23770000, 17IBDG3300328).

Publisher Copyright:
© 2021 World Stroke Organization.

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