InterPro: the integrative protein signature database

Sarah Hunter, Rolf Apweiler, Julian Gough, Derek Wilson, Louise Daugherty, Martin Mandera, Nicola Mulder

Research output: Contribution to journalArticle (Academic Journal)peer-review

1208 Citations (Scopus)

Abstract

The InterPro database (http://www.ebi.ac.uk/interpro/) integrates together predictive models or ‘signatures’ representing protein domains, families and functional sites from multiple, diverse source databases: Gene3D, PANTHER, Pfam, PIRSF, PRINTS, ProDom, PROSITE, SMART, SUPERFAMILY and TIGRFAMs. Integration is performed manually and approximately half of the total ~58 000 signatures available in the source databases belong to an InterPro entry. Recently, we have started to also display the remaining un-integrated signatures via our web interface. Other developments include the provision of non-signature data, such as structural data, in new XML files on our FTP site, as well as the inclusion of matchless UniProtKB proteins in the existing match XML files. The web interface has been extended and now links out to the ADAN predicted protein–protein interaction database and the SPICE and Dasty viewers. The latest public release (v18.0) covers 79.8% of UniProtKB (v14.1) and consists of 16 549 entries. InterPro data may be accessed either via the web address above, via web services, by downloading files by anonymous FTP or by using the InterProScan search software (http://www.ebi.ac.uk/Tools/InterProScan/).
Translated title of the contributionInterPro: the integrative protein signature database
Original languageEnglish
Article numberD211-D215
JournalNucleic Acids Research
Volume37
Publication statusPublished - 2009

Bibliographical note

Other identifier: 2000968

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