Interval Outcomes of a Lifestyle Weight-Loss Intervention in Early Adolescence

Christina Wei, Toby Candler, Elizabeth Crowne, Julian P Hamilton-Shield

Research output: Contribution to journalArticle (Academic Journal)peer-review

186 Downloads (Pure)


We undertook a feasibility study to reassess metabolic outcomes in young people with early onset obesity who attended a hospital-based lifestyle weight-loss intervention during adolescence. Comparisons of metabolic assessments, including body mass index standard deviation scores (BMI⁻SDSs), blood pressure (BP), oral glucose tolerance tests (OGTTs), lipid profile, and alanine transaminase (ALT), before and after treatment were made. Twenty-five subjects (10 males) with median ages (interquartile range, IQR) of 14.5 (12.6⁻15.4) years at the beginning of intervention and 18.2 (17.2⁻18.9) years at reassessment and who were 3.5 (2.4⁻6.5) years post-intervention were recruited. Twenty-eight percent had a ≥0.25 reduction in BMI⁻SDS from baseline (responders). Responders demonstrated significantly lower BMI⁻SDS, systolic BP, and glucose disposal at reassessment compared with baseline. They also showed significantly lower total fat percentage SDSs, trunk fat percentages, 120 min insulin, and ALT, as well as higher insulin sensitivity index (ISIcomp) than non-responders. Male gender and younger age at the initiation of intervention showed a non-significant trend towards greater success in weight loss. Long-term benefits were demonstrated in around one-quarter of obese adolescents after lifestyle modification treatment, with associated improvements in body composition and metabolic parameters.

Original languageEnglish
Article number77
Number of pages6
Issue number6
Early online date15 Jun 2018
Publication statusPublished - Jun 2018


  • adolescents
  • obesity
  • weight management

Fingerprint Dive into the research topics of 'Interval Outcomes of a Lifestyle Weight-Loss Intervention in Early Adolescence'. Together they form a unique fingerprint.

Cite this