TY - JOUR
T1 - Intestinal neoplasia
T2 - A review of 34 cases
AU - Spanton, J. A.
AU - Smith, L. J.
AU - Sherlock, C. E.
AU - Fews, D.
AU - Mair, T. S.
PY - 2018/1/18
Y1 - 2018/1/18
N2 - The clinicopathological features of 34 horses with a histological diagnosis of intestinal neoplasia were reviewed; these included 17 horses with lymphoma, five with gastrointestinal stromal tumours (GISTs), four with adenocarcinomas, three with leiomyosarcomas, two with leiomyomas, two with squamous cell carcinomas (SCC) and one with adenocarcinoma/mesothelioma. The mean age at presentation was 19 years (range 3-36 years), and 81% of cases occurred in horses aged 15 years or older. Weight loss, acute or recurrent colic, inappetence, diarrhoea, depression and pyrexia were the most common presenting clinical signs. Hyperfibrinogenaemia, hypoalbuminaemia and leukocytosis were the most common clinical pathological findings. Transabdominal ultrasonography and exploratory laparotomy were the most useful diagnostic tests. Neoplasia was identified in all regions of the intestinal tract, with the jejunum being most frequently affected. The presence of mass lesions or thickened intestinal walls on transabdominal ultrasound, coupled with other clinical findings, were suggestive of intestinal neoplasia. Where possible, complete surgical resection offered the best prognosis, but generally the prognosis was poor to hopeless.
AB - The clinicopathological features of 34 horses with a histological diagnosis of intestinal neoplasia were reviewed; these included 17 horses with lymphoma, five with gastrointestinal stromal tumours (GISTs), four with adenocarcinomas, three with leiomyosarcomas, two with leiomyomas, two with squamous cell carcinomas (SCC) and one with adenocarcinoma/mesothelioma. The mean age at presentation was 19 years (range 3-36 years), and 81% of cases occurred in horses aged 15 years or older. Weight loss, acute or recurrent colic, inappetence, diarrhoea, depression and pyrexia were the most common presenting clinical signs. Hyperfibrinogenaemia, hypoalbuminaemia and leukocytosis were the most common clinical pathological findings. Transabdominal ultrasonography and exploratory laparotomy were the most useful diagnostic tests. Neoplasia was identified in all regions of the intestinal tract, with the jejunum being most frequently affected. The presence of mass lesions or thickened intestinal walls on transabdominal ultrasound, coupled with other clinical findings, were suggestive of intestinal neoplasia. Where possible, complete surgical resection offered the best prognosis, but generally the prognosis was poor to hopeless.
KW - Abdominal
KW - Colic
KW - Horse
KW - Intestinal
KW - Lymphoma
KW - Neoplasia
UR - http://www.scopus.com/inward/record.url?scp=85040745464&partnerID=8YFLogxK
U2 - 10.1111/eve.12872
DO - 10.1111/eve.12872
M3 - Article (Academic Journal)
AN - SCOPUS:85040745464
JO - Equine Veterinary Education
JF - Equine Veterinary Education
SN - 0957-7734
ER -