Intra-molecular refrigeration in enzymes

Sandu Popescu, H Briegel

Research output: Contribution to journalArticle (Academic Journal)peer-review

6 Citations (Scopus)


We present a simple mechanism for intra-molecular refrigeration, where parts of a molecule are actively cooled below the environmental temperature. We discuss the potential role and applications of such a mechanism in biology, in particular in enzymatic reactions
Original languageEnglish
Article number20110290
JournalProceedings of the Royal Society A: Mathematical, Physical and Engineering Sciences
Issue number2158
Publication statusPublished - 8 Oct 2013


  • Enzymes
  • self-cooling
  • thermodynamics


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