Intracerebroventricular administration of missense oligodeoxynucleotide induces interleukin-6 mRNA expression in brain and spleen of rats

G Pezeshki, B Schöbitz, T Pohl, J M Reul

Research output: Contribution to journalArticle (Academic Journal)peer-review

10 Citations (Scopus)

Abstract

After intracerebroventricular (i.c.v.) injection of a missense oligodeoxynucleotide (MS-ODN) solution in rats, transcripts of the proinflammatory cytokine interleukin (IL)-6 were induced in hypothalamus, hippocampus, cortex and spleen and increased levels of circulating IL-6 and corticosterone were detected. Moreover, using a biotelemetric method body temperature of rats injected with ODN or Ringer solution was monitored over a period of 24 h after the injection. The i.c.v. injection of ODN induced a fever response which peaked at 6 h post-injection. These observations demonstrate that central administration of ODNs generates an inflammatory response in the central nervous system (CNS) and in the periphery as well.

Original languageEnglish
Pages (from-to)97-100
Number of pages4
JournalNeuroscience Letters
Volume217
Issue number2-3
Publication statusPublished - 18 Oct 1996

Keywords

  • Animals
  • Blotting, Northern
  • Brain Chemistry
  • Cerebral Cortex
  • Corticosterone
  • Hippocampus
  • Hypothalamus
  • Injections, Intraventricular
  • Interleukin-6
  • Male
  • Oligonucleotides, Antisense
  • RNA, Messenger
  • Rats
  • Rats, Wistar
  • Spleen

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