Intracerebroventricular administration of streptozotocin as an experimental approach to Alzheimer's disease

Konstantinos Kalafatakis, Apostolos Zarros*

*Corresponding author for this work

Research output: Contribution to journalArticle (Academic Journal)peer-review

8 Citations (Scopus)

Abstract

The in vivo experimental simulation of Alzheimer's disease (AD) has been a field of paramount importance for Experimental Medicine and Neuroscience for more than 20 years. We herein provide a short overview of an experimental approach to sporadic AD that is based on the insulin-resistant state induced in the brains of animals following the intracerebroventricular (icv) administration of streptozotocin (STZ) at low doses. The icv administration of STZ is considered as an established, standardized and reproducible approach to sporadic AD, central aspects of the pathology of which it can reliably simulate.

Original languageEnglish
Pages (from-to)944-946
Number of pages3
JournalInternational Journal of Neuroscience
Volume124
Issue number12
DOIs
Publication statusPublished - 1 Jan 2014

Keywords

  • Alzheimer's disease (AD)
  • Experimental model
  • Streptozotocin (STZ).

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