TY - JOUR
T1 - Intracerebroventricular administration of streptozotocin as an experimental approach to Alzheimer's disease
AU - Kalafatakis, Konstantinos
AU - Zarros, Apostolos
PY - 2014/1/1
Y1 - 2014/1/1
N2 - The in vivo experimental simulation of Alzheimer's disease (AD) has been a field of paramount importance for Experimental Medicine and Neuroscience for more than 20 years. We herein provide a short overview of an experimental approach to sporadic AD that is based on the insulin-resistant state induced in the brains of animals following the intracerebroventricular (icv) administration of streptozotocin (STZ) at low doses. The icv administration of STZ is considered as an established, standardized and reproducible approach to sporadic AD, central aspects of the pathology of which it can reliably simulate.
AB - The in vivo experimental simulation of Alzheimer's disease (AD) has been a field of paramount importance for Experimental Medicine and Neuroscience for more than 20 years. We herein provide a short overview of an experimental approach to sporadic AD that is based on the insulin-resistant state induced in the brains of animals following the intracerebroventricular (icv) administration of streptozotocin (STZ) at low doses. The icv administration of STZ is considered as an established, standardized and reproducible approach to sporadic AD, central aspects of the pathology of which it can reliably simulate.
KW - Alzheimer's disease (AD)
KW - Experimental model
KW - Streptozotocin (STZ).
UR - https://www.scopus.com/pages/publications/84909952142
U2 - 10.3109/00207454.2014.890934
DO - 10.3109/00207454.2014.890934
M3 - Article (Academic Journal)
C2 - 24494726
AN - SCOPUS:84909952142
SN - 0020-7454
VL - 124
SP - 944
EP - 946
JO - International Journal of Neuroscience
JF - International Journal of Neuroscience
IS - 12
ER -