Intracranial spread of IgG4-related disease via skull base foramina

Claire M Rice; T Spencer; G Bunea; Neil J Scolding; P Sloan; U Nath

doi:10.1136/practneurol-2015-001315

Intracranial spread of IgG4-related disease via skull base foramina

Claire M Rice, T Spencer, G Bunea, Neil J Scolding, P Sloan, U Nath

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Abstract

IgG4-related disease (IgG4-RD) is a newly recognised, multiorgan, inflammatory disease, and its full clinical spectrum remains undefined. We present a biopsy-proven case of IgG4-RD presenting with a parapharyngeal mass with intracranial extension and possible involvement of the brain parenchyma. We highlight the importance of considering the diagnosis in those presenting with tumefactive lesions, leptomeningitis or pachymeningitis and emphasise the value of securing a tissue diagnosis so that appropriate long-term treatment can be instigated and complications avoided.

Original language	English
Pages (from-to)	240-242
Number of pages	3
Journal	Practical Neurology
Volume	16
Issue number	3
Early online date	8 Feb 2016
DOIs	https://doi.org/10.1136/practneurol-2015-001315
Publication status	Published - Jun 2016

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IgG4_141015a_PN
This is the author accepted manuscript (AAM). The final published version (version of record) is available online via BMJ at http://pn.bmj.com/content/16/3/240.abstract. Please refer to any applicable terms of use of the publisher.
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IgG4_141015a_PN figures
This is the author accepted manuscript (AAM). The final published version (version of record) is available online via BMJ at http://pn.bmj.com/content/16/3/240.abstract. Please refer to any applicable terms of use of the publisher.
Accepted author manuscript, 673 KB

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title = "Intracranial spread of IgG4-related disease via skull base foramina",

abstract = "IgG4-related disease (IgG4-RD) is a newly recognised, multiorgan, inflammatory disease, and its full clinical spectrum remains undefined. We present a biopsy-proven case of IgG4-RD presenting with a parapharyngeal mass with intracranial extension and possible involvement of the brain parenchyma. We highlight the importance of considering the diagnosis in those presenting with tumefactive lesions, leptomeningitis or pachymeningitis and emphasise the value of securing a tissue diagnosis so that appropriate long-term treatment can be instigated and complications avoided. ",

author = "Rice, {Claire M} and T Spencer and G Bunea and Scolding, {Neil J} and P Sloan and U Nath",

year = "2016",

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T1 - Intracranial spread of IgG4-related disease via skull base foramina

AU - Rice, Claire M

AU - Spencer, T

AU - Bunea, G

AU - Scolding, Neil J

AU - Sloan, P

AU - Nath, U

PY - 2016/6

Y1 - 2016/6

N2 - IgG4-related disease (IgG4-RD) is a newly recognised, multiorgan, inflammatory disease, and its full clinical spectrum remains undefined. We present a biopsy-proven case of IgG4-RD presenting with a parapharyngeal mass with intracranial extension and possible involvement of the brain parenchyma. We highlight the importance of considering the diagnosis in those presenting with tumefactive lesions, leptomeningitis or pachymeningitis and emphasise the value of securing a tissue diagnosis so that appropriate long-term treatment can be instigated and complications avoided.

AB - IgG4-related disease (IgG4-RD) is a newly recognised, multiorgan, inflammatory disease, and its full clinical spectrum remains undefined. We present a biopsy-proven case of IgG4-RD presenting with a parapharyngeal mass with intracranial extension and possible involvement of the brain parenchyma. We highlight the importance of considering the diagnosis in those presenting with tumefactive lesions, leptomeningitis or pachymeningitis and emphasise the value of securing a tissue diagnosis so that appropriate long-term treatment can be instigated and complications avoided.

U2 - 10.1136/practneurol-2015-001315

DO - 10.1136/practneurol-2015-001315

M3 - Article (Academic Journal)

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SN - 1474-7758

VL - 16

SP - 240

EP - 242

JO - Practical Neurology

JF - Practical Neurology

IS - 3

ER -

Intracranial spread of IgG4-related disease via skull base foramina

Abstract

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