Intramolecular arylation of amino acid enolates

Rachel C. Atkinson, Daniel J. Leonard, Julien Maury, Daniele Castagnolo, Nicole Volz, Jonathan Clayden*

*Corresponding author for this work

Research output: Contribution to journalArticle (Academic Journal)

22 Citations (Scopus)

Abstract

Dianionic enolates formed from N′-aryl urea derivatives of amino acids undergo intramolecular C-arylation by attack of the enolate anion on the N′-aryl ring, leading to a hydantoin derivative of a quaternary amino acid. In situ IR studies allow identification of four intermediates on the reaction pathway.

Original languageEnglish
Pages (from-to)9734-9736
Number of pages3
JournalChemical Communications
Volume49
Issue number84
Early online date5 Sep 2013
DOIs
Publication statusPublished - 28 Oct 2013

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