Intrastriatal convection-enhanced delivery results in widespread perivascular distribution in a pre-clinical model

Neil U Barua, Alison S Bienemann, Shirley Hesketh, Marcella J Wyatt, Emma Castrique, Seth Love, Steven S Gill

Research output: Contribution to journalArticle (Academic Journal)peer-review

28 Citations (Scopus)
6 Downloads (Pure)

Abstract

Convection-enhanced delivery (CED), a direct method for drug delivery to the brain through intraparenchymal microcatheters, is a promising strategy for intracerebral pharmacological therapy. By establishing a pressure gradient at the tip of the catheter, drugs can be delivered in uniform concentration throughout a large volume of interstitial fluid. However, the variables affecting perivascular distribution of drugs delivered by CED are not fully understood. The aim of this study was to determine whether the perivascular distribution of solutes delivered by CED into the striatum of rats is affected by the molecular weight of the infused agent, by co-infusion of vasodilator, alteration of infusion rates or use of a ramping regime. We also wanted to make a preliminary comparison of the distribution of solutes with that of nanoparticles.
Translated title of the contributionIntrastriatal convection-enhanced delivery results in widespread perivascular distribution in a pre-clinical model
Original languageEnglish
Article number2
Number of pages12
JournalFluids and Barriers of the CNS
Volume9
DOIs
Publication statusPublished - 20 Jan 2012

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