Introducing vaccination against serogroup B meningococcal disease: An economic and mathematical modelling study of potential impact

Hannah Christensen*, Matthew Hickman, W. John Edmunds, Caroline L. Trotter

*Corresponding author for this work

Research output: Contribution to journalArticle (Academic Journal)peer-review

104 Citations (Scopus)

Abstract

Background: Meningococcal disease remains an important cause of morbidity and mortality worldwide. The first broadly effective vaccine against group B disease (which causes considerable meningococcal disease in Europe, the Americas and Australasia) was licensed in the EU in January 2013; our objective was to estimate the potential impact of introducing such a vaccine in England.

Methods: We developed two models to estimate the impact of introducing a new 'MenB' vaccine. The cohort model assumes the vaccine protects against disease only; the transmission dynamic model also allows the vaccine to protect against carriage (accounting for herd effects). We used these, and economic models, to estimate the case reduction and cost-effectiveness of a number of different vaccine strategies.

Results: We estimate 27% of meningococcal disease cases could be prevented over the lifetime of an English birth cohort by vaccinating infants at 2,3,4 and 12 months of age with a vaccine that prevents disease only; this strategy could be cost-effective at 9 pound per vaccine dose. Substantial reductions in disease (71%) can be produced after 10 years by routinely vaccinating infants in combination with a large-scale catch-up campaign, using a vaccine which protects against carriage as well as disease; this could be cost-effective at 17 pound per vaccine dose.

Conclusions: New 'MenB' vaccines could substantially reduce disease in England and be cost-effective if competitively priced, particularly if the vaccines can prevent carriage as well as disease. These results are relevant to other countries, with a similar epidemiology to England, considering the introduction of a new 'MenB' vaccine. (c) 2013 Elsevier Ltd. All rights reserved.

Original languageEnglish
Pages (from-to)2638-2646
Number of pages9
JournalVaccine
Volume31
Issue number23
DOIs
Publication statusPublished - 28 May 2013

Bibliographical note

Copyright © 2013 Elsevier Ltd. All rights reserved.

Keywords

  • Meningococcal
  • Vaccine
  • Model
  • Cost-effectiveness
  • NEISSERIA-MENINGITIDIS
  • COST-EFFECTIVENESS
  • RANDOMIZED-TRIALS
  • SOCIAL CONTACTS
  • IMMUNOGENICITY
  • DYNAMICS
  • VACCINES
  • MULTICOMPONENT
  • METAANALYSIS
  • CARRIAGE

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