TY - JOUR
T1 - Investigating the contribution of common genetic variants to the risk and pathogenesis of ADHD
AU - Stergiakouli, Evangelia
AU - Hamshere, Marian
AU - Holmans, Peter
AU - Langley, Kate
AU - Zaharieva, Irina
AU - Hawi, Ziarah
AU - Kent, Lindsey
AU - Gill, Michael
AU - Williams, Nigel
AU - Owen, Michael J
AU - O'Donovan, Michael
AU - Thapar, Anita
AU - deCODE Genetics
PY - 2012
Y1 - 2012
N2 - A major motivation for seeking disease-associated genetic variation is to identify novel risk processes. Although rare copy number variants (CNVs) appear to contribute to attention deficit hyperactivity disorder (ADHD), common risk variants (single-nucleotide polymorphisms [SNPs]) have not yet been detected using genome-wide association studies (GWAS). This raises the concern as to whether future larger-scale, adequately powered GWAS will be worthwhile. The authors undertook a GWAS of ADHD and examined whether associated SNPs, including those below conventional levels of significance, influenced the same biological pathways affected by CNVs.
AB - A major motivation for seeking disease-associated genetic variation is to identify novel risk processes. Although rare copy number variants (CNVs) appear to contribute to attention deficit hyperactivity disorder (ADHD), common risk variants (single-nucleotide polymorphisms [SNPs]) have not yet been detected using genome-wide association studies (GWAS). This raises the concern as to whether future larger-scale, adequately powered GWAS will be worthwhile. The authors undertook a GWAS of ADHD and examined whether associated SNPs, including those below conventional levels of significance, influenced the same biological pathways affected by CNVs.
M3 - Article (Academic Journal)
C2 - 22420046
SN - 0002-953X
VL - 169
SP - 186
EP - 194
JO - American Journal of Psychiatry
JF - American Journal of Psychiatry
IS - 2
ER -