Investigating the contribution of common genetic variants to the risk and pathogenesis of ADHD

Evangelia Stergiakouli, Marian Hamshere, Peter Holmans, Kate Langley, Irina Zaharieva, Ziarah Hawi, Lindsey Kent, Michael Gill, Nigel Williams, Michael J Owen, Michael O'Donovan, Anita Thapar, deCODE Genetics

Research output: Contribution to journalArticle (Academic Journal)peer-review

143 Citations (Scopus)

Abstract

A major motivation for seeking disease-associated genetic variation is to identify novel risk processes. Although rare copy number variants (CNVs) appear to contribute to attention deficit hyperactivity disorder (ADHD), common risk variants (single-nucleotide polymorphisms [SNPs]) have not yet been detected using genome-wide association studies (GWAS). This raises the concern as to whether future larger-scale, adequately powered GWAS will be worthwhile. The authors undertook a GWAS of ADHD and examined whether associated SNPs, including those below conventional levels of significance, influenced the same biological pathways affected by CNVs.
Original languageEnglish
Pages (from-to)186-94
Number of pages9
JournalAmerican Journal of Psychiatry
Volume169
Issue number2
Publication statusPublished - 2012

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