Investigating the roles of different monoamine transmitters and impulse control using the 5-choice serial reaction time task

Clara S. Humpston, Christian M. Wood, Emma S. J. Robinson*

*Corresponding author for this work

Research output: Contribution to journalArticle (Academic Journal)peer-review

22 Citations (Scopus)

Abstract

Previous studies have shown that drugs which block the reuptake of catecholamine neurotransmitters improve impulse control in diseases such as attention deficit hyperactivity disorder (ADHD). Serotonin-specific reuptake inhibitors (SSRI) lack efficacy in ADHD and have been linked to increased suicide risk. The present study investigated drugs with affinity for one or more of the monoamine reuptake transporters using the 5-choice serial reaction time task, a model of attention and impulsivity in rodents. We also tested the effects of the alpha2-adreoceptor antagonist, idazoxan and novel antidepressant, agomelatine, which both increase cortical noradrenaline concentrations through non-reuptake mechanisms. Improvements in impulse control were observed with venlafaxine, a serotonin and noradrenaline re-uptake inhibitor (SNRI) but not bupropion (dopamine and noradrenaline re-uptake inhibitor). Sibutramine (SNRI) reduced premature responses by similar to 50% at the highest dose tested but this was not significant. All three of the SSRIs tested reduced premature responding in a dose-dependent manner, although also slowed response and collection latencies. Neither idazoxan nor agomelatine significantly reduced premature responding, suggesting a lack of efficacy at the doses tested. None of the drugs tested improved attention in this task but sibutramine (SNRI), fluoxetine (SSRI) and paroxetine (SSRI) all increased omissions at the highest dose tested. These data suggest that the SNRIs and SSRIs reduce premature responding but tend to be less specific than noradrenaline specific reuptake inhibitors in this model. SSRIs did not induce any specific impairment in impulse control in this model.

Original languageEnglish
Pages (from-to)213-221
Number of pages9
JournalJournal of Psychopharmacology
Volume27
Issue number2
DOIs
Publication statusPublished - Feb 2013

Keywords

  • Noradrenaline
  • dopamine
  • serotonin
  • attention
  • impulsivity
  • 5-choice serial reaction time task
  • ADHD
  • rat
  • monoamine reuptake
  • RAT FRONTAL-CORTEX
  • ATTENTION-DEFICIT/HYPERACTIVITY DISORDER
  • NORADRENALINE REUPTAKE INHIBITOR
  • BORDERLINE PERSONALITY-DISORDER
  • PREFRONTAL CORTEX
  • IN-VIVO
  • D-AMPHETAMINE
  • EXTRACELLULAR CONCENTRATIONS
  • NOREPINEPHRINE TRANSPORTER
  • FUNCTIONAL NEUROCHEMISTRY

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