Investigating whether adverse prenatal and perinatal events are associated with non-clinical psychotic symptoms at age 12 years in the ALSPAC birth cohort

Stanley Zammit, D. Odd, James Horwood, A. Thompson, Kate Thomas, P. Menezes, D. Gunnell, C. Hollis, D. Wolke, Glyn H Lewis, Gillian Harrison

Research output: Contribution to journalArticle (Academic Journal)peer-review

79 Citations (Scopus)

Abstract

Background Non-clinical psychosis-like symptoms (PLIKS) occur in about 15% of the population. It is not clear whether adverse events during early development alter the risk of developing PLIKS. We aimed to examine whether maternal infection, diabetes or pre-eclampsia during pregnancy, gestational age, perinatal cardiopulmonary resuscitation or 5-min Apgar score were associated with development of psychotic symptoms during early adolescence. Method A longitudinal study of 6356 12-year-old adolescents who completed a semi-structured interview for psychotic symptoms in the Avon Longitudinal Study of Parents and Children (ALSPAC) birth cohort. Prenatal and perinatal data were obtained from obstetric records and maternal questionnaires completed during pregnancy. Results The presence of definite psychotic symptoms was associated with maternal infection during pregnancy [adjusted odds ratio (OR) 1.44, 95% confidence interval (CI) 1.11?1.86, p=0.006], maternal diabetes (adjusted OR 3.43, 95% CI 1.14?10.36, p=0.029), need for resuscitation (adjusted OR 1.50, 95% CI 0.97?2.31, p=0.065) and 5-min Apgar score (adjusted OR per unit decrease 1.30, 95% CI 1.12?1.50, p
Original languageEnglish
Pages (from-to)1457-1467
Number of pages11
JournalPsychological Medicine
Volume39
Issue number9
DOIs
Publication statusPublished - 1 Sep 2009

Bibliographical note

Pdf uploaded in accordance with publisher's policy at http://www.sherpa.ac.uk/romeo/issn/0033-2917/ (accessed 25/02/2014).

Keywords

  • Cohort study
  • obstetric complications
  • pregnancy
  • psychotic symptoms

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