TY - JOUR
T1 - Investigating whether adverse prenatal and perinatal events are associated with non-clinical psychotic symptoms at age 12 years in the ALSPAC birth cohort
AU - Zammit, Stanley
AU - Odd, D.
AU - Horwood, James
AU - Thompson, A.
AU - Thomas, Kate
AU - Menezes, P.
AU - Gunnell, D.
AU - Hollis, Chris
AU - Wolke, D.
AU - Lewis, Glyn H
AU - Harrison, Gillian
N1 - Pdf uploaded in accordance with publisher's policy at http://www.sherpa.ac.uk/romeo/issn/0033-2917/ (accessed 25/02/2014).
PY - 2009/9/1
Y1 - 2009/9/1
N2 - Background Non-clinical psychosis-like symptoms (PLIKS) occur in about 15% of the population. It is not clear whether adverse events during early development alter the risk of developing PLIKS. We aimed to examine whether maternal infection, diabetes or pre-eclampsia during pregnancy, gestational age, perinatal cardiopulmonary resuscitation or 5-min Apgar score were associated with development of psychotic symptoms during early adolescence. Method A longitudinal study of 6356 12-year-old adolescents who completed a semi-structured interview for psychotic symptoms in the Avon Longitudinal Study of Parents and Children (ALSPAC) birth cohort. Prenatal and perinatal data were obtained from obstetric records and maternal questionnaires completed during pregnancy. Results The presence of definite psychotic symptoms was associated with maternal infection during pregnancy [adjusted odds ratio (OR) 1.44, 95% confidence interval (CI) 1.11?1.86, p=0.006], maternal diabetes (adjusted OR 3.43, 95% CI 1.14?10.36, p=0.029), need for resuscitation (adjusted OR 1.50, 95% CI 0.97?2.31, p=0.065) and 5-min Apgar score (adjusted OR per unit decrease 1.30, 95% CI 1.12?1.50, p
AB - Background Non-clinical psychosis-like symptoms (PLIKS) occur in about 15% of the population. It is not clear whether adverse events during early development alter the risk of developing PLIKS. We aimed to examine whether maternal infection, diabetes or pre-eclampsia during pregnancy, gestational age, perinatal cardiopulmonary resuscitation or 5-min Apgar score were associated with development of psychotic symptoms during early adolescence. Method A longitudinal study of 6356 12-year-old adolescents who completed a semi-structured interview for psychotic symptoms in the Avon Longitudinal Study of Parents and Children (ALSPAC) birth cohort. Prenatal and perinatal data were obtained from obstetric records and maternal questionnaires completed during pregnancy. Results The presence of definite psychotic symptoms was associated with maternal infection during pregnancy [adjusted odds ratio (OR) 1.44, 95% confidence interval (CI) 1.11?1.86, p=0.006], maternal diabetes (adjusted OR 3.43, 95% CI 1.14?10.36, p=0.029), need for resuscitation (adjusted OR 1.50, 95% CI 0.97?2.31, p=0.065) and 5-min Apgar score (adjusted OR per unit decrease 1.30, 95% CI 1.12?1.50, p
KW - Cohort study
KW - obstetric complications
KW - pregnancy
KW - psychotic symptoms
UR - http://orca.cf.ac.uk/29729/
U2 - 10.1017/S0033291708005126
DO - 10.1017/S0033291708005126
M3 - Article (Academic Journal)
C2 - 19215630
SN - 0033-2917
VL - 39
SP - 1457
EP - 1467
JO - Psychological Medicine
JF - Psychological Medicine
IS - 9
ER -