Investigation of Crohn's disease risk loci in ulcerative colitis further defines their molecular relationship

Carl A Anderson, Dunecan C O Massey, Jeffrey C Barrett, Natalie J Prescott, Mark Tremelling, Sheila A Fisher, Rhian Gwilliam, Jemima Jacob, Elaine R Nimmo, Hazel Drummond, Charlie W Lees, Clive M Onnie, Catherine Hanson, Katarzyna Blaszczyk, Radhi Ravindrarajah, Sarah Hunt, Dhiraj Varma, Naomi Hammond, Gregory Lewis, Heather AttleseyNick Watkins, Willem Ouwehand, David Strachan, Wendy McArdle, Cathryn M Lewis, Alan Lobo, Jeremy Sanderson, Derek P Jewell, Panos Deloukas, John C Mansfield, Christopher G Mathew, Jack Satsangi, Miles Parkes, Wellcome Trust Case Control Consortium

Research output: Contribution to journalArticle (Academic Journal)peer-review

146 Citations (Scopus)

Abstract

Identifying shared and disease-specific susceptibility loci for Crohn's disease (CD) and ulcerative colitis (UC) would help define the biologic relationship between the inflammatory bowel diseases. More than 30 CD susceptibility loci have been identified. These represent important candidate susceptibility loci for UC. Loci discovered by the index genome scans in CD have previously been tested for association with UC, but those identified in the recent meta-analysis await such investigation. Furthermore, the recently identified UC locus at ECM1 requires formal testing for association with CD.
Original languageEnglish
Pages (from-to)523-9.e3
JournalGastroenterology
Volume136
Issue number2
DOIs
Publication statusPublished - 2009

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