Involvement of astrocyte and oligodendrocyte gene sets in migraine

Else Eising, Christiaan de Leeuw, Josine L Min, Verneri Anttila, Mark Hg Verheijen, Gisela M Terwindt, Martin Dichgans, Tobias Freilinger, Christian Kubisch, Michel D Ferrari, August B Smit, Boukje de Vries, Aarno Palotie, Arn Mjm van den Maagdenberg, Danielle Posthuma, International Headache Genetics Consortium

Research output: Contribution to journalArticle (Academic Journal)peer-review

15 Citations (Scopus)
308 Downloads (Pure)


BACKGROUND: Migraine is a common episodic brain disorder characterized by recurrent attacks of severe unilateral headache and additional neurological symptoms. Two main migraine types can be distinguished based on the presence of aura symptoms that can accompany the headache: migraine with aura and migraine without aura. Multiple genetic and environmental factors confer disease susceptibility. Recent genome-wide association studies (GWAS) indicate that migraine susceptibility genes are involved in various pathways, including neurotransmission, which have already been implicated in genetic studies of monogenic familial hemiplegic migraine, a subtype of migraine with aura.

METHODS: To further explore the genetic background of migraine, we performed a gene set analysis of migraine GWAS data of 4954 clinic-based patients with migraine, as well as 13,390 controls. Curated sets of synaptic genes and sets of genes predominantly expressed in three glial cell types (astrocytes, microglia and oligodendrocytes) were investigated.

DISCUSSION: Our results show that gene sets containing astrocyte- and oligodendrocyte-related genes are associated with migraine, which is especially true for gene sets involved in protein modification and signal transduction. Observed differences between migraine with aura and migraine without aura indicate that both migraine types, at least in part, seem to have a different genetic background.

Original languageEnglish
Pages (from-to)640-647
Number of pages8
Issue number7
Early online date7 Dec 2015
Publication statusPublished - 1 Jun 2016


  • Migraine
  • GWAS
  • Pathway analysis
  • astrocytes
  • oligodendrocytes
  • synapse


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