Abstract
Although the replacement of ubiquitous palladium catalysts with more sustainable iron-based analogues continues apace, the simple biaryl Suzuki cross-coupling reaction remains stubbornly elusive. It appears that the main issue hampering the reaction is activation of the aryl halide C-X bond. Here we show that a simple N-pyrrole amide and related directing groups on the aryl halide substrates facilitate this process by transient π-coordination to the iron centre. This allows iron-catalysed Suzuki biaryl cross-coupling to proceed, under mild conditions, with alkyllithium-activated aryl pinacol boronic esters.
Original language | English |
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Pages (from-to) | 429-437 |
Number of pages | 9 |
Journal | Nature Catalysis |
Volume | 1 |
Issue number | 6 |
Early online date | 12 Jun 2018 |
DOIs | |
Publication status | Published - Jun 2018 |
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Dive into the research topics of 'Iron-catalysed substrate-directed Suzuki biaryl cross-coupling'. Together they form a unique fingerprint.Datasets
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Iron-Catalysed Suzuki Nature Catalysis 2018
Bedford, R. (Creator), O'Brien, H. (Creator), Manzotti, M. (Creator) & Davis, S. (Creator), University of Bristol, 24 May 2018
DOI: 10.5523/bris.1egk09qs16sej2ru76yju7q572, http://data.bris.ac.uk/data/dataset/1egk09qs16sej2ru76yju7q572
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Profiles
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Dr Sean A Davis
- School of Chemistry - Senior Lecturer
- Soft Matter, Colloids and Materials
Person: Academic , Member