Iron-catalysed Suzuki coupling? A cautionary tale

Robin B. Bedford, Masaharu Nakamura, Nicholas J. Gower, Mairi F. Haddow, Mark A. Hall, Michael Huwe, Tohru Hashimoto, Rukeme A. Okopie

Research output: Contribution to journalArticle (Academic Journal)peer-review

56 Citations (Scopus)


In our hands, Fe(II) or (III) pyridine complexes show no activity in Suzuki biaryl cross-coupling reactions, except in one irreproducible instance when complete conversion was observed. A comparison with palladium acetate under the same conditions showed that complete conversion can be obtained in a S:C ratio of 1,000,000:1 and therefore extreme caution must be exercised to prevent 'false-positives' arising from trace Pd-contaminants. (C) 2009 Elsevier Ltd. All rights reserved.

Original languageEnglish
Pages (from-to)6110-6111
Number of pages2
JournalTetrahedron Letters
Issue number45
Publication statusPublished - 11 Nov 2009


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