Iron-phosphine, -phosphite, -arsine, and -carbene catalysts for the coupling of primary and secondary alkyl halides with aryl Grignard reagents

RB Bedford, M Betham, DW Bruce, AA Danapoulos, RM Frost, M Hird

Research output: Contribution to journalArticle (Academic Journal)peer-review

244 Citations (Scopus)

Abstract

Simple catalysts formed in situ from iron chloride and a wide range of monodentate and bidentate phosphines and arsines have been screened in the coupling of alkyl halides bearing -hydrogens with aryl Grignard reagents. The best of these show excellent activity, as do catalysts formed in situ with monodentate trialkyl and triaryl phosphite ligands. N-heterocyclic carbene-based precatalysts, either preformed or made in situ, also show excellent performance.
Translated title of the contributionIron-phosphine, -phosphite, -arsine, and -carbene catalysts for the coupling of primary and secondary alkyl halides with aryl Grignard reagents
Original languageEnglish
Pages (from-to)1104 - 1110
Number of pages7
JournalJournal of Organic Chemistry
Volume71 (3)
DOIs
Publication statusPublished - Feb 2006

Bibliographical note

Publisher: American Chemical Society

Fingerprint Dive into the research topics of 'Iron-phosphine, -phosphite, -arsine, and -carbene catalysts for the coupling of primary and secondary alkyl halides with aryl Grignard reagents'. Together they form a unique fingerprint.

Cite this