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Iron-catalysed substrate-directed Suzuki biaryl cross-coupling

Research output: Contribution to journalArticle

Original languageEnglish
Pages (from-to)429-437
Number of pages9
JournalNature Catalysis
Issue number6
DateAccepted/In press - 24 Apr 2018
DatePublished (current) - 1 Jun 2018


Although the replacement of ubiquitous palladium catalysts with more sustainable iron-based analogues continues apace, the simple biaryl Suzuki cross-coupling reaction remains stubbornly elusive. It appears that the main issue hampering the reaction is activation of the aryl halide C-X bond. Here we show that a simple N-pyrrole amide and related directing groups on the aryl halide substrates facilitate this process by transient π-coordination to the iron centre. This allows iron-catalysed Suzuki biaryl cross-coupling to proceed, under mild conditions, with alkyllithium-activated aryl pinacol boronic esters.

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