Bibliographical noteFunding Information:
No formal funding was used for this article, but FH's time was covered by the GW4 CAT Wellcome Doctoral training scheme. RJL is funded by the NIHR ARC West Midlands. This research was funded in whole, or in part, by the Wellcome Trust. For the purpose of Open Access, the author has applied a CC BY public copyright licence to any Author Accepted Manuscript version arising from this submission.
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