Is disrupted sleep a risk factor for Alzheimer’s disease? Evidence from a two-sample Mendelian randomization analysis

Emma L Anderson; Rebecca Richmond; Samuel E Jones; Gibran Hemani; Kaitlin H Wade; Hassan S Dashti; Jacqueline M. Lane; Heming Wang; Richa Saxena; Ben M Brumpton; Roxanna S Korologou-Linden; Jonas Bille  Nielsen; Bjørn Olav Asvold; Goncalo R Abecasis; E J Coulthard; Simon D. Kyle; Robin N Beaumont; Jessica Tyrrell; Timothy Frayling; Marcus R Munafo; Andrew R. Wood; Yoav Ben-Shlomo; Laura D Howe; Debbie A Lawlor; Michael N Weedon; George Davey Smith

Is disrupted sleep a risk factor for Alzheimer’s disease? Evidence from a two-sample Mendelian randomization analysis

Emma L Anderson^*, Rebecca Richmond, Samuel E Jones, Gibran Hemani, Kaitlin H Wade, Hassan S Dashti, Jacqueline M. Lane, Heming Wang, Richa Saxena, Ben M Brumpton, Roxanna S Korologou-Linden, Jonas Bille Nielsen, Bjørn Olav Asvold, Goncalo R Abecasis, E J Coulthard, Simon D. Kyle, Robin N Beaumont, Jessica Tyrrell, Timothy Frayling, Marcus R MunafoAndrew R. Wood, Yoav Ben-Shlomo, Laura D Howe, Debbie A Lawlor, Michael N Weedon, George Davey Smith

^*Corresponding author for this work

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Abstract

INTRODUCTION: It is established that Alzheimer’s disease (AD) patients experience sleep disruption. However, it remains unknown whether disruption in the quantity, quality or timing of sleep is a risk factor for the onset of AD.

METHODS Mendelian randomization (MR) was used to estimate the causal effect of self-reported and accelerometer-measured sleep parameters (chronotype, duration, fragmentation, insomnia, daytime napping and daytime sleepiness) on AD risk.

RESULTS Overall, there was little evidence that sleep traits affect the risk of AD. There was some evidence to suggest that self-reported daytime napping was associated with lower AD risk (odds ratio [OR]: 0.70, 95% confidence interval [CI]: 0.50 to 0.99). Some other sleep traits (accelerometer-measured eveningness and sleep duration, and self-reported daytime sleepiness) had ORs for AD risk of a similar magnitude to daytime napping, but were less precisely estimated.

DISCUSSON Our findings provide tentative evidence that daytime napping may reduce AD risk. However, findings should be replicated using independent samples.

Original language	English
Journal	International Journal of Epidemiology
Publication status	Accepted/In press - 28 Jul 2020

Structured keywords

Brain and Behaviour

Keywords

Sleep
Alzheimer’s disease
Dementia
Mendelian randomization
Causal Inference

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2 Active

8073 MRC IEU - Programme 6
Lawlor, D. A.
1/04/18 → 31/03/23
Project: Research
IEU: MRC Integrative Epidemiology Unit Quinquennial renewal
Gaunt, L. F. & Davey Smith, G.
1/04/18 → 31/03/23
Project: Research

Dr Emma L Anderson
- Emma.Louise.Anderson@bristol.ac.uk
- Bristol Medical School (PHS) - Research Fellow
- Bristol Population Health Science Institute
- MRC Integrative Epidemiology Unit
Person: Academic , Member

Cite this

Anderson, E. L., Richmond, R., Jones, S. E., Hemani, G., Wade, K. H., Dashti, H. S., Lane, J. M., Wang, H., Saxena, R., Brumpton, B. M., Korologou-Linden, R. S., Nielsen, J. B., Asvold, B. O., Abecasis, G. R., Coulthard, E. J., Kyle, S. D., Beaumont, R. N., Tyrrell, J., Frayling, T., ... Davey Smith, G. (Accepted/In press). Is disrupted sleep a risk factor for Alzheimer’s disease? Evidence from a two-sample Mendelian randomization analysis. International Journal of Epidemiology.

Anderson, Emma L ; Richmond, Rebecca ; Jones, Samuel E ; Hemani, Gibran ; Wade, Kaitlin H ; Dashti, Hassan S ; Lane, Jacqueline M. ; Wang, Heming ; Saxena, Richa ; Brumpton, Ben M ; Korologou-Linden, Roxanna S ; Nielsen, Jonas Bille ; Asvold, Bjørn Olav ; Abecasis, Goncalo R ; Coulthard, E J ; Kyle, Simon D. ; Beaumont, Robin N ; Tyrrell, Jessica ; Frayling, Timothy ; Munafo, Marcus R ; Wood, Andrew R. ; Ben-Shlomo, Yoav ; Howe, Laura D ; Lawlor, Debbie A ; Weedon, Michael N ; Davey Smith, George. / Is disrupted sleep a risk factor for Alzheimer’s disease? Evidence from a two-sample Mendelian randomization analysis. In: International Journal of Epidemiology. 2020.

@article{db1c549b513d4ee1b16ab5876fcbad42,

title = "Is disrupted sleep a risk factor for Alzheimer{\textquoteright}s disease? Evidence from a two-sample Mendelian randomization analysis",

abstract = "INTRODUCTION: It is established that Alzheimer{\textquoteright}s disease (AD) patients experience sleep disruption. However, it remains unknown whether disruption in the quantity, quality or timing of sleep is a risk factor for the onset of AD. METHODS Mendelian randomization (MR) was used to estimate the causal effect of self-reported and accelerometer-measured sleep parameters (chronotype, duration, fragmentation, insomnia, daytime napping and daytime sleepiness) on AD risk. RESULTS Overall, there was little evidence that sleep traits affect the risk of AD. There was some evidence to suggest that self-reported daytime napping was associated with lower AD risk (odds ratio [OR]: 0.70, 95% confidence interval [CI]: 0.50 to 0.99). Some other sleep traits (accelerometer-measured eveningness and sleep duration, and self-reported daytime sleepiness) had ORs for AD risk of a similar magnitude to daytime napping, but were less precisely estimated. DISCUSSON Our findings provide tentative evidence that daytime napping may reduce AD risk. However, findings should be replicated using independent samples.",

keywords = "Sleep, Alzheimer{\textquoteright}s disease, Dementia, Mendelian randomization, Causal Inference",

author = "Anderson, {Emma L} and Rebecca Richmond and Jones, {Samuel E} and Gibran Hemani and Wade, {Kaitlin H} and Dashti, {Hassan S} and Lane, {Jacqueline M.} and Heming Wang and Richa Saxena and Brumpton, {Ben M} and Korologou-Linden, {Roxanna S} and Nielsen, {Jonas Bille} and Asvold, {Bj{\o}rn Olav} and Abecasis, {Goncalo R} and Coulthard, {E J} and Kyle, {Simon D.} and Beaumont, {Robin N} and Jessica Tyrrell and Timothy Frayling and Munafo, {Marcus R} and Wood, {Andrew R.} and Yoav Ben-Shlomo and Howe, {Laura D} and Lawlor, {Debbie A} and Weedon, {Michael N} and {Davey Smith}, George",

year = "2020",

month = jul,

day = "28",

language = "English",

journal = "International Journal of Epidemiology",

issn = "0300-5771",

publisher = "Oxford University Press",

}

Anderson, EL , Richmond, R, Jones, SE, Hemani, G , Wade, KH, Dashti, HS, Lane, JM, Wang, H, Saxena, R, Brumpton, BM, Korologou-Linden, RS, Nielsen, JB, Asvold, BO, Abecasis, GR, Coulthard, EJ, Kyle, SD, Beaumont, RN, Tyrrell, J, Frayling, T, Munafo, MR, Wood, AR, Ben-Shlomo, Y , Howe, LD , Lawlor, DA, Weedon, MN & Davey Smith, G 2020, 'Is disrupted sleep a risk factor for Alzheimer’s disease? Evidence from a two-sample Mendelian randomization analysis', International Journal of Epidemiology.

Is disrupted sleep a risk factor for Alzheimer’s disease? Evidence from a two-sample Mendelian randomization analysis. / Anderson, Emma L ; Richmond, Rebecca; Jones, Samuel E; Hemani, Gibran ; Wade, Kaitlin H; Dashti, Hassan S; Lane, Jacqueline M.; Wang, Heming; Saxena, Richa; Brumpton, Ben M; Korologou-Linden, Roxanna S; Nielsen, Jonas Bille ; Asvold, Bjørn Olav; Abecasis, Goncalo R; Coulthard, E J; Kyle, Simon D.; Beaumont, Robin N; Tyrrell, Jessica; Frayling, Timothy; Munafo, Marcus R; Wood, Andrew R.; Ben-Shlomo, Yoav ; Howe, Laura D ; Lawlor, Debbie A; Weedon, Michael N; Davey Smith, George.

In: International Journal of Epidemiology, 28.07.2020.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

TY - JOUR

T1 - Is disrupted sleep a risk factor for Alzheimer’s disease? Evidence from a two-sample Mendelian randomization analysis

AU - Anderson, Emma L

AU - Richmond, Rebecca

AU - Jones, Samuel E

AU - Hemani, Gibran

AU - Wade, Kaitlin H

AU - Dashti, Hassan S

AU - Lane, Jacqueline M.

AU - Wang, Heming

AU - Saxena, Richa

AU - Brumpton, Ben M

AU - Korologou-Linden, Roxanna S

AU - Nielsen, Jonas Bille

AU - Asvold, Bjørn Olav

AU - Abecasis, Goncalo R

AU - Coulthard, E J

AU - Kyle, Simon D.

AU - Beaumont, Robin N

AU - Tyrrell, Jessica

AU - Frayling, Timothy

AU - Munafo, Marcus R

AU - Wood, Andrew R.

AU - Ben-Shlomo, Yoav

AU - Howe, Laura D

AU - Lawlor, Debbie A

AU - Weedon, Michael N

AU - Davey Smith, George

PY - 2020/7/28

Y1 - 2020/7/28

N2 - INTRODUCTION: It is established that Alzheimer’s disease (AD) patients experience sleep disruption. However, it remains unknown whether disruption in the quantity, quality or timing of sleep is a risk factor for the onset of AD. METHODS Mendelian randomization (MR) was used to estimate the causal effect of self-reported and accelerometer-measured sleep parameters (chronotype, duration, fragmentation, insomnia, daytime napping and daytime sleepiness) on AD risk. RESULTS Overall, there was little evidence that sleep traits affect the risk of AD. There was some evidence to suggest that self-reported daytime napping was associated with lower AD risk (odds ratio [OR]: 0.70, 95% confidence interval [CI]: 0.50 to 0.99). Some other sleep traits (accelerometer-measured eveningness and sleep duration, and self-reported daytime sleepiness) had ORs for AD risk of a similar magnitude to daytime napping, but were less precisely estimated. DISCUSSON Our findings provide tentative evidence that daytime napping may reduce AD risk. However, findings should be replicated using independent samples.

AB - INTRODUCTION: It is established that Alzheimer’s disease (AD) patients experience sleep disruption. However, it remains unknown whether disruption in the quantity, quality or timing of sleep is a risk factor for the onset of AD. METHODS Mendelian randomization (MR) was used to estimate the causal effect of self-reported and accelerometer-measured sleep parameters (chronotype, duration, fragmentation, insomnia, daytime napping and daytime sleepiness) on AD risk. RESULTS Overall, there was little evidence that sleep traits affect the risk of AD. There was some evidence to suggest that self-reported daytime napping was associated with lower AD risk (odds ratio [OR]: 0.70, 95% confidence interval [CI]: 0.50 to 0.99). Some other sleep traits (accelerometer-measured eveningness and sleep duration, and self-reported daytime sleepiness) had ORs for AD risk of a similar magnitude to daytime napping, but were less precisely estimated. DISCUSSON Our findings provide tentative evidence that daytime napping may reduce AD risk. However, findings should be replicated using independent samples.

KW - Sleep

KW - Alzheimer’s disease

KW - Dementia

KW - Mendelian randomization

KW - Causal Inference

M3 - Article (Academic Journal)

JO - International Journal of Epidemiology

JF - International Journal of Epidemiology

SN - 0300-5771

ER -

Is disrupted sleep a risk factor for Alzheimer’s disease? Evidence from a two-sample Mendelian randomization analysis

Abstract

Structured keywords

Keywords

Embargoed Document

8073 MRC IEU - Programme 6

IEU: MRC Integrative Epidemiology Unit Quinquennial renewal

Dr Emma L Anderson

Cite this