Is having asthma associated with an increased risk of dying from cardiovascular disease?: A prospective cohort study of 446 346 Taiwanese adults

Linn Beate Strand; Min Kuang Tsai; Chi Pang Wen; Shu-Sen Chang; Ben M Brumpton

doi:10.1136/bmjopen-2017-019992

Is having asthma associated with an increased risk of dying from cardiovascular disease? A prospective cohort study of 446 346 Taiwanese adults

Linn Beate Strand
, Min Kuang Tsai
, Chi Pang Wen
, Shu-Sen Chang
, Ben M Brumpton

Research output: Contribution to journal › Article (Academic Journal) › peer-review

51 Citations (Scopus)

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Abstract

OBJECTIVES: A significant proportion of cardiovascular disease (CVD) cannot be explained by well-known risk factors such as high cholesterol, hypertension and diabetes. One potential novel risk factor for CVD is asthma. We aimed to investigate the association between asthma and mortality due to CVD.

DESIGN: Prospective cohort study.

SETTING: A large health check-up programme from 1994 to 2011 in Taipei, Taiwan.

PARTICIPANTS: 446 346 Taiwanese adults. Each participant answered questions regarding asthma history (yes/no) and current daily use of asthma medications (yes/no). Active asthma was defined as those using current daily medications for asthma.

OUTCOMES: The participants were followed for mortality from CVD, coronary heart disease (CHD) and stroke obtained through linkage to the cause-of-death register until 31 December 2011.

RESULTS: We found an increased risk of dying from CVD in individuals with active asthma (adjusted HR (aHR) 1.32, 95% CI 1.08 to 1.62). The risk of death from CHD or stroke was increased in a similar manner (aHR 1.16, 95% CI 0.78 to 1.73 and aHR 1.23, 95% CI 0.86 to 1.74, respectively) although the HR estimates were less precise than that of CVD. For deaths from CVD, CHD and stroke, we found stronger associations with active asthma than non-active asthma, and for CVD and stroke stronger associations in men than women.

CONCLUSION: Our study suggests that asthma, particularly active asthma, may be associated with adverse cardiovascular consequences.

Original language	English
Article number	e019992
Number of pages	8
Journal	BMJ Open
Volume	8
Issue number	5
Early online date	31 May 2018
DOIs	https://doi.org/10.1136/bmjopen-2017-019992
Publication status	E-pub ahead of print - 31 May 2018

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This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

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@article{fff7a5022a5949f2b766843bba84c64d,

title = "Is having asthma associated with an increased risk of dying from cardiovascular disease?: A prospective cohort study of 446 346 Taiwanese adults",

abstract = "OBJECTIVES: A significant proportion of cardiovascular disease (CVD) cannot be explained by well-known risk factors such as high cholesterol, hypertension and diabetes. One potential novel risk factor for CVD is asthma. We aimed to investigate the association between asthma and mortality due to CVD.DESIGN: Prospective cohort study.SETTING: A large health check-up programme from 1994 to 2011 in Taipei, Taiwan.PARTICIPANTS: 446 346 Taiwanese adults. Each participant answered questions regarding asthma history (yes/no) and current daily use of asthma medications (yes/no). Active asthma was defined as those using current daily medications for asthma.OUTCOMES: The participants were followed for mortality from CVD, coronary heart disease (CHD) and stroke obtained through linkage to the cause-of-death register until 31 December 2011.RESULTS: We found an increased risk of dying from CVD in individuals with active asthma (adjusted HR (aHR) 1.32, 95\% CI 1.08 to 1.62). The risk of death from CHD or stroke was increased in a similar manner (aHR 1.16, 95\% CI 0.78 to 1.73 and aHR 1.23, 95\% CI 0.86 to 1.74, respectively) although the HR estimates were less precise than that of CVD. For deaths from CVD, CHD and stroke, we found stronger associations with active asthma than non-active asthma, and for CVD and stroke stronger associations in men than women.CONCLUSION: Our study suggests that asthma, particularly active asthma, may be associated with adverse cardiovascular consequences.",

author = "Strand, \{Linn Beate\} and Tsai, \{Min Kuang\} and Wen, \{Chi Pang\} and Shu-Sen Chang and Brumpton, \{Ben M\}",

note = "{\textcopyright} Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2018. All rights reserved. No commercial use is permitted unless otherwise expressly granted.",

year = "2018",

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doi = "10.1136/bmjopen-2017-019992",

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T1 - Is having asthma associated with an increased risk of dying from cardiovascular disease?

T2 - A prospective cohort study of 446 346 Taiwanese adults

AU - Strand, Linn Beate

AU - Tsai, Min Kuang

AU - Wen, Chi Pang

AU - Chang, Shu-Sen

AU - Brumpton, Ben M

PY - 2018/5/31

Y1 - 2018/5/31

N2 - OBJECTIVES: A significant proportion of cardiovascular disease (CVD) cannot be explained by well-known risk factors such as high cholesterol, hypertension and diabetes. One potential novel risk factor for CVD is asthma. We aimed to investigate the association between asthma and mortality due to CVD.DESIGN: Prospective cohort study.SETTING: A large health check-up programme from 1994 to 2011 in Taipei, Taiwan.PARTICIPANTS: 446 346 Taiwanese adults. Each participant answered questions regarding asthma history (yes/no) and current daily use of asthma medications (yes/no). Active asthma was defined as those using current daily medications for asthma.OUTCOMES: The participants were followed for mortality from CVD, coronary heart disease (CHD) and stroke obtained through linkage to the cause-of-death register until 31 December 2011.RESULTS: We found an increased risk of dying from CVD in individuals with active asthma (adjusted HR (aHR) 1.32, 95% CI 1.08 to 1.62). The risk of death from CHD or stroke was increased in a similar manner (aHR 1.16, 95% CI 0.78 to 1.73 and aHR 1.23, 95% CI 0.86 to 1.74, respectively) although the HR estimates were less precise than that of CVD. For deaths from CVD, CHD and stroke, we found stronger associations with active asthma than non-active asthma, and for CVD and stroke stronger associations in men than women.CONCLUSION: Our study suggests that asthma, particularly active asthma, may be associated with adverse cardiovascular consequences.

AB - OBJECTIVES: A significant proportion of cardiovascular disease (CVD) cannot be explained by well-known risk factors such as high cholesterol, hypertension and diabetes. One potential novel risk factor for CVD is asthma. We aimed to investigate the association between asthma and mortality due to CVD.DESIGN: Prospective cohort study.SETTING: A large health check-up programme from 1994 to 2011 in Taipei, Taiwan.PARTICIPANTS: 446 346 Taiwanese adults. Each participant answered questions regarding asthma history (yes/no) and current daily use of asthma medications (yes/no). Active asthma was defined as those using current daily medications for asthma.OUTCOMES: The participants were followed for mortality from CVD, coronary heart disease (CHD) and stroke obtained through linkage to the cause-of-death register until 31 December 2011.RESULTS: We found an increased risk of dying from CVD in individuals with active asthma (adjusted HR (aHR) 1.32, 95% CI 1.08 to 1.62). The risk of death from CHD or stroke was increased in a similar manner (aHR 1.16, 95% CI 0.78 to 1.73 and aHR 1.23, 95% CI 0.86 to 1.74, respectively) although the HR estimates were less precise than that of CVD. For deaths from CVD, CHD and stroke, we found stronger associations with active asthma than non-active asthma, and for CVD and stroke stronger associations in men than women.CONCLUSION: Our study suggests that asthma, particularly active asthma, may be associated with adverse cardiovascular consequences.

U2 - 10.1136/bmjopen-2017-019992

DO - 10.1136/bmjopen-2017-019992

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JO - BMJ Open

JF - BMJ Open

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