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Abstract
This Editorial highlights a study by Hunsberger et al. (2015) in the current issue of Journal of Neurochemistry, in which the authors explore the effects of riluzole (R) treatment on tau-P301L transgenic mice. The authors employed a comprehensive analysis of possible restorative effects of the drug by examining glutamate levels in subregions of the hippocampus, expression of tau and its hyper-phosphorylated forms, and memory function using behavioral tests. The authors report a simultaneous reduction in glutamate reuptake and an increase in glutamate release in the tau-P301L model, both of which are ameliorated with riluzole treatment. The authors' findings have implications for our understanding of synaptic transmission mechanisms also associated with Alzheimer's disease pathology.
Original language | English |
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Pages (from-to) | 207-209 |
Number of pages | 3 |
Journal | Journal of Neurochemistry |
Volume | 135 |
Issue number | 2 |
Early online date | 7 Sep 2015 |
DOIs | |
Publication status | Published - 9 Oct 2015 |
Keywords
- Alzheimer's disease (AD)
- riluzole
- tau
- glutamate transporter
- PSD-95
- hyperexcitability
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- 1 Finished
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Development of biotin-tagged affinity ligands and fluorophore-conjugated probes for the study of native kainate receptors
1/03/13 → 1/03/16
Project: Research