Is the recent rise in type 2 diabetes incidence from 1984 to 2007 explained by the trend in increasing BMI?: evidence from a prospective study of British men

Sarah L Hardoon; Richard W Morris; Mary C Thomas; S Goya Wannamethee; Lucy T Lennon; Peter H Whincup

doi:10.2337/dc09-2295

Is the recent rise in type 2 diabetes incidence from 1984 to 2007 explained by the trend in increasing BMI? evidence from a prospective study of British men

Sarah L Hardoon, Richard W Morris, Mary C Thomas, S Goya Wannamethee, Lucy T Lennon, Peter H Whincup

Research output: Contribution to journal › Article (Academic Journal) › peer-review

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Abstract

OBJECTIVE: To estimate the extent to which increasing BMI may explain the rise in type 2 diabetes incidence in British men from 1984 to 2007.

RESEARCH DESIGN AND METHODS: A representative cohort ratio of 6,460 British men was followed-up for type 2 diabetes incidence between 1984 (aged 45-65 years) and 2007 (aged 67-89 years). BMI was ascertained at regular intervals before and during the follow-up.

RESULTS: Between 1984-1992 and 1999-2007, the age-adjusted hazard of type 2 diabetes more than doubled (hazard ratio 2.33 [95% CI 1.75-3.10]). Mean BMI rose by 1.42 kg/m(2) (95% CI 1.10-1.74) between 1984 and 1999; this could explain 26% (95% CI 17-38) of the type 2 diabetes increase.

CONCLUSIONS: An appreciable portion of the rise in type 2 diabetes can be attributed to BMI changes. A substantial portion remains unexplained, possibly associated with other determinants such as physical activity. This merits further research.

Original language	English
Pages (from-to)	1494-1496
Number of pages	3
Journal	Diabetes Care
Volume	33
Issue number	7
DOIs	https://doi.org/10.2337/dc09-2295
Publication status	Published - Jul 2010

Keywords

Adipose Tissue
Age Distribution
Aged
Aged, 80 and over
Body Mass Index
Cohort Studies
Diabetes Mellitus, Type 2
Follow-Up Studies
Great Britain
Humans
Incidence
Male
Middle Aged
Prospective Studies

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@article{ad9678ffe4e646c0914a907f2466b508,

title = "Is the recent rise in type 2 diabetes incidence from 1984 to 2007 explained by the trend in increasing BMI?: evidence from a prospective study of British men",

abstract = "OBJECTIVE: To estimate the extent to which increasing BMI may explain the rise in type 2 diabetes incidence in British men from 1984 to 2007.RESEARCH DESIGN AND METHODS: A representative cohort ratio of 6,460 British men was followed-up for type 2 diabetes incidence between 1984 (aged 45-65 years) and 2007 (aged 67-89 years). BMI was ascertained at regular intervals before and during the follow-up.RESULTS: Between 1984-1992 and 1999-2007, the age-adjusted hazard of type 2 diabetes more than doubled (hazard ratio 2.33 [95% CI 1.75-3.10]). Mean BMI rose by 1.42 kg/m(2) (95% CI 1.10-1.74) between 1984 and 1999; this could explain 26% (95% CI 17-38) of the type 2 diabetes increase.CONCLUSIONS: An appreciable portion of the rise in type 2 diabetes can be attributed to BMI changes. A substantial portion remains unexplained, possibly associated with other determinants such as physical activity. This merits further research.",

keywords = "Adipose Tissue, Age Distribution, Aged, Aged, 80 and over, Body Mass Index, Cohort Studies, Diabetes Mellitus, Type 2, Follow-Up Studies, Great Britain, Humans, Incidence, Male, Middle Aged, Prospective Studies",

author = "Hardoon, {Sarah L} and Morris, {Richard W} and Thomas, {Mary C} and Wannamethee, {S Goya} and Lennon, {Lucy T} and Whincup, {Peter H}",

year = "2010",

month = jul,

doi = "10.2337/dc09-2295",

language = "English",

volume = "33",

pages = "1494--1496",

journal = "Diabetes Care",

issn = "0149-5992",

publisher = "American Diabetes Association Inc.",

number = "7",

}

TY - JOUR

T1 - Is the recent rise in type 2 diabetes incidence from 1984 to 2007 explained by the trend in increasing BMI?

T2 - evidence from a prospective study of British men

AU - Hardoon, Sarah L

AU - Morris, Richard W

AU - Thomas, Mary C

AU - Wannamethee, S Goya

AU - Lennon, Lucy T

AU - Whincup, Peter H

PY - 2010/7

Y1 - 2010/7

N2 - OBJECTIVE: To estimate the extent to which increasing BMI may explain the rise in type 2 diabetes incidence in British men from 1984 to 2007.RESEARCH DESIGN AND METHODS: A representative cohort ratio of 6,460 British men was followed-up for type 2 diabetes incidence between 1984 (aged 45-65 years) and 2007 (aged 67-89 years). BMI was ascertained at regular intervals before and during the follow-up.RESULTS: Between 1984-1992 and 1999-2007, the age-adjusted hazard of type 2 diabetes more than doubled (hazard ratio 2.33 [95% CI 1.75-3.10]). Mean BMI rose by 1.42 kg/m(2) (95% CI 1.10-1.74) between 1984 and 1999; this could explain 26% (95% CI 17-38) of the type 2 diabetes increase.CONCLUSIONS: An appreciable portion of the rise in type 2 diabetes can be attributed to BMI changes. A substantial portion remains unexplained, possibly associated with other determinants such as physical activity. This merits further research.

AB - OBJECTIVE: To estimate the extent to which increasing BMI may explain the rise in type 2 diabetes incidence in British men from 1984 to 2007.RESEARCH DESIGN AND METHODS: A representative cohort ratio of 6,460 British men was followed-up for type 2 diabetes incidence between 1984 (aged 45-65 years) and 2007 (aged 67-89 years). BMI was ascertained at regular intervals before and during the follow-up.RESULTS: Between 1984-1992 and 1999-2007, the age-adjusted hazard of type 2 diabetes more than doubled (hazard ratio 2.33 [95% CI 1.75-3.10]). Mean BMI rose by 1.42 kg/m(2) (95% CI 1.10-1.74) between 1984 and 1999; this could explain 26% (95% CI 17-38) of the type 2 diabetes increase.CONCLUSIONS: An appreciable portion of the rise in type 2 diabetes can be attributed to BMI changes. A substantial portion remains unexplained, possibly associated with other determinants such as physical activity. This merits further research.

KW - Adipose Tissue

KW - Age Distribution

KW - Aged

KW - Aged, 80 and over

KW - Body Mass Index

KW - Cohort Studies

KW - Diabetes Mellitus, Type 2

KW - Follow-Up Studies

KW - Great Britain

KW - Humans

KW - Incidence

KW - Male

KW - Middle Aged

KW - Prospective Studies

U2 - 10.2337/dc09-2295

DO - 10.2337/dc09-2295

M3 - Article (Academic Journal)

C2 - 20413526

SN - 0149-5992

VL - 33

SP - 1494

EP - 1496

JO - Diabetes Care

JF - Diabetes Care

IS - 7

ER -