Abstract
OBJECTIVE: To estimate the extent to which increasing BMI may explain the rise in type 2 diabetes incidence in British men from 1984 to 2007.
RESEARCH DESIGN AND METHODS: A representative cohort ratio of 6,460 British men was followed-up for type 2 diabetes incidence between 1984 (aged 45-65 years) and 2007 (aged 67-89 years). BMI was ascertained at regular intervals before and during the follow-up.
RESULTS: Between 1984-1992 and 1999-2007, the age-adjusted hazard of type 2 diabetes more than doubled (hazard ratio 2.33 [95% CI 1.75-3.10]). Mean BMI rose by 1.42 kg/m(2) (95% CI 1.10-1.74) between 1984 and 1999; this could explain 26% (95% CI 17-38) of the type 2 diabetes increase.
CONCLUSIONS: An appreciable portion of the rise in type 2 diabetes can be attributed to BMI changes. A substantial portion remains unexplained, possibly associated with other determinants such as physical activity. This merits further research.
Original language | English |
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Pages (from-to) | 1494-1496 |
Number of pages | 3 |
Journal | Diabetes Care |
Volume | 33 |
Issue number | 7 |
DOIs | |
Publication status | Published - Jul 2010 |
Keywords
- Adipose Tissue
- Age Distribution
- Aged
- Aged, 80 and over
- Body Mass Index
- Cohort Studies
- Diabetes Mellitus, Type 2
- Follow-Up Studies
- Great Britain
- Humans
- Incidence
- Male
- Middle Aged
- Prospective Studies