Is tocilizumab a potential therapeutic option for refractory unicentric Castleman disease?

Muhammad Bilal Abid, Rachel Peck, Muhammad Abbas Abid, Wesam Al-Sakkaf, Yuening Zhang, Giles S Dunnill, Konrad Staines, Iara M Sequeiros, Lisa Lowry

Research output: Contribution to journalArticle (Academic Journal)peer-review

7 Citations (Scopus)
403 Downloads (Pure)

Abstract

Castleman’s Disease is a rare lymphoproliferative disorder with two distinctly defined clinical forms. While multi-centric Castleman’s disease (MCD) poses a potential therapeutic challenge, unicentric variant (UCD) has historically been considered curable with surgical resection. Hence, little is known to guide management of patients with UCD, refractory to surgical resection and combination chemotherapy. We present a case of a patient, negative for HIV and HHV-8, who had an unsuccessful surgical intervention and no response to radiotherapy and chemotherapy. He had severe paraneoplastic pemphigus and was treated with tocilizumab, an anti-interleukin-6 receptor monoclonal antibody that has demonstrated good response rates in MCD, but demonstrated no clinical response despite two months of treatment. Our report is the first to describe a lack of response to tocilizumab in the rare setting of refractory UCD and discuss potential for distinct disease biology.
Original languageEnglish
Pages (from-to)320-323
Number of pages4
JournalHematological Oncology
Volume36
Issue number1
Early online date11 Apr 2017
DOIs
Publication statusPublished - Feb 2018

Keywords

  • Unicentric Castleman’s Disease (UCD)
  • Tocilizumab
  • Interleukin-6 (IL-6)
  • Cytokine storm

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