Is useful research data usually shared? An investigation of genome-wide association study summary statistics

Mike Thelwall*, Marcus Munafò, Amalia Mas-Bleda, Emma Stuart, Meiko Makita, Verena Weigert, Chris Keene, Nushrat Khan, Katie Drax, Kayvan Kousha

*Corresponding author for this work

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Abstract

Primary data collected during a research study is often shared and may be reused for new studies. To assess the extent of data sharing in favourable circumstances and whether data sharing checks can be automated, this article investigates summary statistics from primary human genome-wide association studies (GWAS). This type of data is highly suitable for sharing because it is a standard research output, is straightforward to use in future studies (e.g., for secondary analysis), and may be already stored in a standard format for internal sharing within multi-site research projects. Manual checks of 1799 articles from 2010 and 2017 matching a simple PubMed query for molecular epidemiology GWAS were used to identify 314 primary human GWAS papers. Of these, only 13% reported the location of a complete set of GWAS summary data, increasing from 3% in 2010 to 23% in 2017. Whilst information about whether data was shared was typically located clearly within a data availability statement, the exact nature of the shared data was usually unspecified. Thus, data sharing is the exception even in suitable research fields with relatively strong data sharing norms. Moreover, the lack of clear data descriptions within data sharing statements greatly complicates the task of automatically characterising shared data sets.

Original languageEnglish
Pages (from-to)e0229578
Number of pages11
JournalPLoS ONE
Volume15
Issue number2
DOIs
Publication statusPublished - 21 Feb 2020

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Structured keywords

  • Physical and Mental Health

Cite this

Thelwall, M., Munafò, M., Mas-Bleda, A., Stuart, E., Makita, M., Weigert, V., Keene, C., Khan, N., Drax, K., & Kousha, K. (2020). Is useful research data usually shared? An investigation of genome-wide association study summary statistics. PLoS ONE, 15(2), e0229578. https://doi.org/10.1371/journal.pone.0229578