Isoform-specific functions of protein kinase C: the platelet paradigm

M T Harper, A W Poole

Research output: Contribution to journalArticle (Academic Journal)

37 Citations (Scopus)

Abstract

Platelets are central to haemostasis and thrombosis. Many key steps in platelet activation and aggregation are regulated by members of the PKC (protein kinase C) family. Multiple isoforms of PKC are expressed in platelets, and evidence is emerging that different isoforms play distinct roles in the platelet activation process. This may, in part, be regulated by isoform-specific interactions between PKC family members and other intracellular signalling molecules, such as tyrosine kinases, or the actin cytoskeleton regulator, VASP (vasodilator-stimulated phosphoprotein). The contributions of individual PKC isoforms can be addressed directly in platelets from knockout mouse models, which are providing key insights into the physiological function of PKC isoform diversity and can be a valuable complimentary approach to more commonly used pharmacological analyses. Using knockout mouse models, recent reports have demonstrated the importance of PKCbeta and PKCtheta in integrin-dependent platelet spreading, and also a novel role for PKCdelta in regulating filopodial formation, highlighting the utility of such models to investigate the functions of specific PKC isoforms in a physiological process that is significant to our understanding of cardiovascular disease.
Original languageEnglish
Pages (from-to)1005-8
Number of pages4
JournalBiochemical Society Transactions
Volume35
Issue numberPt 5
DOIs
Publication statusPublished - Nov 2007

Keywords

  • Models, Animal
  • Animals
  • Blood Platelets
  • Humans
  • Isoenzymes
  • Platelet Activation
  • Mice
  • Protein Kinase C

Fingerprint Dive into the research topics of 'Isoform-specific functions of protein kinase C: the platelet paradigm'. Together they form a unique fingerprint.

  • Cite this