Isolating the Effect of Arch Architecture on Aortic Hemodynamics Late After Coarctation Repair: A Computational Study

Vahid Goodarzi Ardakani, Harshinee Goordoyal, M. Victoria Ordonez, Froso Sophocleous, Stephanie L Curtis, Radwa Bedair, Massimo Caputo, Alberto M Gambaruto, Giovanni Biglino

Research output: Contribution to journalArticle (Academic Journal)peer-review

2 Citations (Scopus)
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Objectives: Effective management of aortic coarctation (CoA) affects long-term cardiovascular outcomes. Full appreciation of CoA hemodynamics is important. This study aimed to analyze the relationship between aortic shape and hemodynamic parameters by means of computational simulations, purposely isolating the morphological variable.

Methods: Computational simulations were run in three aortic models. MRI-derived aortic geometries were generated using a statistical shape modeling methodology. Starting from n = 108 patients, the mean aortic configuration was derived in patients without CoA (n = 37, “no-CoA”), with surgically repaired CoA (n = 58, “r-CoA”) and with unrepaired CoA (n = 13, “CoA”). As such, the aortic models represented average configurations for each scenario. Key hemodynamic parameters (i.e., pressure drop, aortic velocity, vorticity, wall shear stress WSS, and length and number of strong flow separations in the descending aorta) were measured in the three models at three time points (peak systole, end systole, end diastole).

Results: Comparing no-CoA and CoA revealed substantial differences in all hemodynamic parameters. However, simulations revealed significant increases in vorticity at the site of CoA repair, higher WSS in the descending aorta and a 12% increase in power loss, in r-CoA compared to no-CoA, despite no clinically significant narrowing (CoA index >0.8) in the r-CoA model.

Conclusions: Small alterations in aortic morphology impact on key hemodynamic indices. This may contribute to explaining phenomena such as persistent hypertension in the absence of any clinically significant narrowing. Whilst cardiovascular events in these patients may be related to hypertension, the role of arch geometry may be a contributory factor.
Original languageEnglish
Article number855118
Number of pages10
JournalFrontiers in Cardiovascular Medicine
Publication statusPublished - 24 Jun 2022

Bibliographical note

Funding Information:
VGA acknowledges support from the University of Bristol to carry out his Ph.D. Also, the authors gratefully acknowledge the support of the British Heart Foundation (Prof. Caputo's Chair and the Bristol BHF Accelerator Award) and the Bristol NIHR Biomedical Research Center (BRC).

Publisher Copyright:
Copyright © 2022 Goodarzi Ardakani, Goordoyal, Ordonez, Sophocleous, Curtis, Bedair, Caputo, Gambaruto and Biglino.


  • aortic coarctation
  • aortic hemodynamics
  • computational modeling
  • computational fluid dynamics
  • power loss
  • wall shear stress


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