Strongyloides ratti and S. venezuelensis – rodent models of Strongyloides infection

Mark Viney; Taisei Kikuchi

doi:10.1017/S0031182016000020

Strongyloides ratti and S. venezuelensis – rodent models of Strongyloides infection

Mark Viney, Taisei Kikuchi

Research output: Contribution to journal › Special issue (Academic Journal) › peer-review

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Abstract

Strongyloides spp. are common parasites of vertebrates and two species, S. ratti and S. venezuelensis, parasitize rats; there are no known species that naturally infect mice. Strongyloides ratti and S. venezuelensis overlap in their geographical range and in these regions co-infections appear to be common. These species have been widely used as tractable laboratory systems in rats as well as mice. The core biology of these two species is similar, but there are clear differences in aspects of their within-host biology as well as in their free-living generation. Phylogenetic evidence suggests that S. ratti and S. venezuelensis are the result of two independent evolutionary transitions to parasitism of rats, which therefore presents an ideal opportunity to begin to investigate the basis of host specificity in Strongyloides spp.

Original language	English
Pages (from-to)	285-294
Number of pages	10
Journal	Parasitology
Volume	144
Issue number	3
Early online date	3 Mar 2016
DOIs	https://doi.org/10.1017/S0031182016000020
Publication status	Published - Mar 2017

Keywords

Strongyloides
rats
rodent

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10.1017/S0031182016000020

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abstract = "Strongyloides spp. are common parasites of vertebrates and two species, S. ratti and S. venezuelensis, parasitize rats; there are no known species that naturally infect mice. Strongyloides ratti and S. venezuelensis overlap in their geographical range and in these regions co-infections appear to be common. These species have been widely used as tractable laboratory systems in rats as well as mice. The core biology of these two species is similar, but there are clear differences in aspects of their within-host biology as well as in their free-living generation. Phylogenetic evidence suggests that S. ratti and S. venezuelensis are the result of two independent evolutionary transitions to parasitism of rats, which therefore presents an ideal opportunity to begin to investigate the basis of host specificity in Strongyloides spp.",

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AU - Viney, Mark

AU - Kikuchi, Taisei

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N2 - Strongyloides spp. are common parasites of vertebrates and two species, S. ratti and S. venezuelensis, parasitize rats; there are no known species that naturally infect mice. Strongyloides ratti and S. venezuelensis overlap in their geographical range and in these regions co-infections appear to be common. These species have been widely used as tractable laboratory systems in rats as well as mice. The core biology of these two species is similar, but there are clear differences in aspects of their within-host biology as well as in their free-living generation. Phylogenetic evidence suggests that S. ratti and S. venezuelensis are the result of two independent evolutionary transitions to parasitism of rats, which therefore presents an ideal opportunity to begin to investigate the basis of host specificity in Strongyloides spp.

AB - Strongyloides spp. are common parasites of vertebrates and two species, S. ratti and S. venezuelensis, parasitize rats; there are no known species that naturally infect mice. Strongyloides ratti and S. venezuelensis overlap in their geographical range and in these regions co-infections appear to be common. These species have been widely used as tractable laboratory systems in rats as well as mice. The core biology of these two species is similar, but there are clear differences in aspects of their within-host biology as well as in their free-living generation. Phylogenetic evidence suggests that S. ratti and S. venezuelensis are the result of two independent evolutionary transitions to parasitism of rats, which therefore presents an ideal opportunity to begin to investigate the basis of host specificity in Strongyloides spp.

KW - Strongyloides

KW - rats

KW - rodent

U2 - 10.1017/S0031182016000020

DO - 10.1017/S0031182016000020

M3 - Special issue (Academic Journal)

C2 - 26935155

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SP - 285

EP - 294

JO - Parasitology

JF - Parasitology

SN - 0031-1820

IS - 3

ER -

Strongyloides ratti and S. venezuelensis – rodent models of Strongyloides infection

Abstract

Keywords

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