Joint associations of depression, genetic susceptibility and the area of residence for coronary heart disease incidence

Karri Silventoinen; Kaarina  Korhonen; Hannu  Lahtinen; Aline Jelenkovic; Aki S Havulinna; Samuli Ripatti; Veikko Salomaa; George Davey Smith; Pekka Martikainen

doi:10.1136/jech-2021-216451

Joint associations of depression, genetic susceptibility and the area of residence for coronary heart disease incidence

Karri Silventoinen^*, Kaarina Korhonen, Hannu Lahtinen, Aline Jelenkovic, Aki S Havulinna, Samuli Ripatti, Veikko Salomaa, George Davey Smith, Pekka Martikainen

^*Corresponding author for this work

Research output: Contribution to journal › Article (Academic Journal) › peer-review

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Abstract

Background Depression is a risk factor for coronary heart disease (CHD), but less is known whether genetic susceptibility to CHD or regional-level social indicators modify this association.

Methods Risk factors of CHD including a Polygenic Risk Score (PRS) were measured for 19 999 individuals residing in Finland in 1997, 2002, 2007 and 2012 (response rates 60%–75%). During the register-based follow-up until 2015, there were 1381 fatal and non-fatal incident CHD events. Unemployment rate, degree of urbanisation and crime rate of the municipality of residence were used as regional level social indicators. HRs were calculated using register-based antidepressant purchases as a non-reversible time-dependent covariate.

Results Those having depression and in the highest quartile of PRS had somewhat higher CHD risk than predicted only by the main effects of depression and PRS (HR for interaction 1.53, 95% CI 0.95 to 2.45). Depression was moderately associated with CHD in high crime (HR 1.51, 95% CI 1.20 to 1.90) and weakly in low crime regions (HR 1.07, 95% CI 0.86 to 1.33; p value of interaction=0.087). Otherwise, we did not found evidence for interactions.

Conclusions Those having both depression and high genetic susceptibility need a special attention in healthcare for CHD.

Original language	English
Article number	202203
Pages (from-to)	281-284
Number of pages	4
Journal	Journal of Epidemiology and Community Health
Volume	76
Issue number	3
Early online date	18 Aug 2021
DOIs	https://doi.org/10.1136/jech-2021-216451
Publication status	Published - 10 Feb 2022

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© Author(s) (or their employer(s)) 2022. No commercial re-use. See rights and permissions. Published by BMJ.

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IEU: MRC Integrative Epidemiology Unit Quinquennial renewal
Gaunt, L. F. (Principal Investigator) & Davey Smith, G. (Principal Investigator)
1/04/18 → 31/03/23
Project: Research

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Silventoinen, K., Korhonen, K., Lahtinen, H., Jelenkovic, A., Havulinna, A. S., Ripatti, S., Salomaa, V., Davey Smith, G., & Martikainen, P. (2022). Joint associations of depression, genetic susceptibility and the area of residence for coronary heart disease incidence. Journal of Epidemiology and Community Health, 76(3), 281-284. Article 202203. https://doi.org/10.1136/jech-2021-216451

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title = "Joint associations of depression, genetic susceptibility and the area of residence for coronary heart disease incidence",

abstract = "Background Depression is a risk factor for coronary heart disease (CHD), but less is known whether genetic susceptibility to CHD or regional-level social indicators modify this association. Methods Risk factors of CHD including a Polygenic Risk Score (PRS) were measured for 19 999 individuals residing in Finland in 1997, 2002, 2007 and 2012 (response rates 60\%–75\%). During the register-based follow-up until 2015, there were 1381 fatal and non-fatal incident CHD events. Unemployment rate, degree of urbanisation and crime rate of the municipality of residence were used as regional level social indicators. HRs were calculated using register-based antidepressant purchases as a non-reversible time-dependent covariate. Results Those having depression and in the highest quartile of PRS had somewhat higher CHD risk than predicted only by the main effects of depression and PRS (HR for interaction 1.53, 95\% CI 0.95 to 2.45). Depression was moderately associated with CHD in high crime (HR 1.51, 95\% CI 1.20 to 1.90) and weakly in low crime regions (HR 1.07, 95\% CI 0.86 to 1.33; p value of interaction=0.087). Otherwise, we did not found evidence for interactions. Conclusions Those having both depression and high genetic susceptibility need a special attention in healthcare for CHD.",

author = "Karri Silventoinen and Kaarina Korhonen and Hannu Lahtinen and Aline Jelenkovic and Havulinna, \{Aki S\} and Samuli Ripatti and Veikko Salomaa and \{Davey Smith\}, George and Pekka Martikainen",

note = "Publisher Copyright: {\textcopyright} Author(s) (or their employer(s)) 2022. No commercial re-use. See rights and permissions. Published by BMJ.",

year = "2022",

month = feb,

day = "10",

doi = "10.1136/jech-2021-216451",

language = "English",

volume = "76",

pages = "281--284",

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Silventoinen, K, Korhonen, K, Lahtinen, H, Jelenkovic, A, Havulinna, AS, Ripatti, S, Salomaa, V, Davey Smith, G & Martikainen, P 2022, 'Joint associations of depression, genetic susceptibility and the area of residence for coronary heart disease incidence', Journal of Epidemiology and Community Health, vol. 76, no. 3, 202203, pp. 281-284. https://doi.org/10.1136/jech-2021-216451

Joint associations of depression, genetic susceptibility and the area of residence for coronary heart disease incidence. / Silventoinen, Karri; Korhonen, Kaarina ; Lahtinen, Hannu et al.
In: Journal of Epidemiology and Community Health, Vol. 76, No. 3, 202203, 10.02.2022, p. 281-284.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

TY - JOUR

T1 - Joint associations of depression, genetic susceptibility and the area of residence for coronary heart disease incidence

AU - Silventoinen, Karri

AU - Korhonen, Kaarina

AU - Lahtinen, Hannu

AU - Jelenkovic, Aline

AU - Havulinna, Aki S

AU - Ripatti, Samuli

AU - Salomaa, Veikko

AU - Davey Smith, George

AU - Martikainen, Pekka

PY - 2022/2/10

Y1 - 2022/2/10

N2 - Background Depression is a risk factor for coronary heart disease (CHD), but less is known whether genetic susceptibility to CHD or regional-level social indicators modify this association. Methods Risk factors of CHD including a Polygenic Risk Score (PRS) were measured for 19 999 individuals residing in Finland in 1997, 2002, 2007 and 2012 (response rates 60%–75%). During the register-based follow-up until 2015, there were 1381 fatal and non-fatal incident CHD events. Unemployment rate, degree of urbanisation and crime rate of the municipality of residence were used as regional level social indicators. HRs were calculated using register-based antidepressant purchases as a non-reversible time-dependent covariate. Results Those having depression and in the highest quartile of PRS had somewhat higher CHD risk than predicted only by the main effects of depression and PRS (HR for interaction 1.53, 95% CI 0.95 to 2.45). Depression was moderately associated with CHD in high crime (HR 1.51, 95% CI 1.20 to 1.90) and weakly in low crime regions (HR 1.07, 95% CI 0.86 to 1.33; p value of interaction=0.087). Otherwise, we did not found evidence for interactions. Conclusions Those having both depression and high genetic susceptibility need a special attention in healthcare for CHD.

AB - Background Depression is a risk factor for coronary heart disease (CHD), but less is known whether genetic susceptibility to CHD or regional-level social indicators modify this association. Methods Risk factors of CHD including a Polygenic Risk Score (PRS) were measured for 19 999 individuals residing in Finland in 1997, 2002, 2007 and 2012 (response rates 60%–75%). During the register-based follow-up until 2015, there were 1381 fatal and non-fatal incident CHD events. Unemployment rate, degree of urbanisation and crime rate of the municipality of residence were used as regional level social indicators. HRs were calculated using register-based antidepressant purchases as a non-reversible time-dependent covariate. Results Those having depression and in the highest quartile of PRS had somewhat higher CHD risk than predicted only by the main effects of depression and PRS (HR for interaction 1.53, 95% CI 0.95 to 2.45). Depression was moderately associated with CHD in high crime (HR 1.51, 95% CI 1.20 to 1.90) and weakly in low crime regions (HR 1.07, 95% CI 0.86 to 1.33; p value of interaction=0.087). Otherwise, we did not found evidence for interactions. Conclusions Those having both depression and high genetic susceptibility need a special attention in healthcare for CHD.

U2 - 10.1136/jech-2021-216451

DO - 10.1136/jech-2021-216451

M3 - Article (Academic Journal)

C2 - 34407993

SN - 0143-005X

VL - 76

SP - 281

EP - 284

JO - Journal of Epidemiology and Community Health

JF - Journal of Epidemiology and Community Health

IS - 3

M1 - 202203

ER -

Joint associations of depression, genetic susceptibility and the area of residence for coronary heart disease incidence

Abstract

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IEU: MRC Integrative Epidemiology Unit Quinquennial renewal

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