Kainate Receptors and Synaptic Plasticity

Jithin D Nair; Kevin A Wilkinson; Jeremy M Henley; Jack R Mellor

doi:10.1016/j.neuropharm.2021.108540

Kainate Receptors and Synaptic Plasticity

Jithin D Nair, Kevin A Wilkinson, Jeremy M Henley, Jack R Mellor^*

^*Corresponding author for this work

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Abstract

Synaptic plasticity has classically been characterized to involve the NMDA and AMPA subtypes of glutamate receptors, with NMDA receptors providing the key trigger for the induction of long-term plasticity leading to changes in AMPA receptor expression. Here we review the more subtle roles played by kainate receptors, which contribute critical postsynaptic signalling as well as playing major presynaptic auto-receptor roles. We focus on two research areas: plasticity of kainate receptors themselves and the contribution they make to the plasticity of synaptic transmission.

Translated title of the contribution	Kainate receptors and synaptic plasticity
Original language	English
Article number	108540
Pages (from-to)	957
Number of pages	1
Journal	Neuropharmacology
Volume	406
Issue number	6799
Early online date	30 Mar 2021
DOIs	https://doi.org/10.1016/j.neuropharm.2021.108540
Publication status	Published - 15 Sept 2021

Keywords

kainate receptors
synaptic plasticity
hippocampus
CA3
mossy fiber

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10.1016/j.neuropharm.2021.108540

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title = "Kainate Receptors and Synaptic Plasticity",

abstract = "Synaptic plasticity has classically been characterized to involve the NMDA and AMPA subtypes of glutamate receptors, with NMDA receptors providing the key trigger for the induction of long-term plasticity leading to changes in AMPA receptor expression. Here we review the more subtle roles played by kainate receptors, which contribute critical postsynaptic signalling as well as playing major presynaptic auto-receptor roles. We focus on two research areas: plasticity of kainate receptors themselves and the contribution they make to the plasticity of synaptic transmission.",

keywords = "kainate receptors, synaptic plasticity, hippocampus, CA3, mossy fiber",

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AU - Nair, Jithin D

AU - Wilkinson, Kevin A

AU - Henley, Jeremy M

AU - Mellor, Jack R

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N2 - Synaptic plasticity has classically been characterized to involve the NMDA and AMPA subtypes of glutamate receptors, with NMDA receptors providing the key trigger for the induction of long-term plasticity leading to changes in AMPA receptor expression. Here we review the more subtle roles played by kainate receptors, which contribute critical postsynaptic signalling as well as playing major presynaptic auto-receptor roles. We focus on two research areas: plasticity of kainate receptors themselves and the contribution they make to the plasticity of synaptic transmission.

AB - Synaptic plasticity has classically been characterized to involve the NMDA and AMPA subtypes of glutamate receptors, with NMDA receptors providing the key trigger for the induction of long-term plasticity leading to changes in AMPA receptor expression. Here we review the more subtle roles played by kainate receptors, which contribute critical postsynaptic signalling as well as playing major presynaptic auto-receptor roles. We focus on two research areas: plasticity of kainate receptors themselves and the contribution they make to the plasticity of synaptic transmission.

KW - kainate receptors

KW - synaptic plasticity

KW - hippocampus

KW - CA3

KW - mossy fiber

U2 - 10.1016/j.neuropharm.2021.108540

DO - 10.1016/j.neuropharm.2021.108540

M3 - Article (Academic Journal)

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SP - 957

JO - Neuropharmacology

JF - Neuropharmacology

IS - 6799

M1 - 108540

ER -

Kainate Receptors and Synaptic Plasticity

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