Kawasaki disease and coronary artery aneurysms: From childhood to adulthood

Manjiri Joshi, Robert Tulloh*

*Corresponding author for this work

Research output: Contribution to journalReview article (Academic Journal)peer-review

1 Citation (Scopus)
306 Downloads (Pure)

Abstract

Kawasaki disease is an acute, systemic vasculitis of childhood and confers a 25% risk of developing coronary artery aneurysms. Its etiology is unknown, but the incidence is increasing rapidly with linked gene polymorphisms having been identified. A constellation of symptoms, epidemics and seasonality all implicate an unidentified infective or environmental cause. Intravenous immunoglobulin therapy, aspirin and steroids all form the mainstay of acute treatment and reduces the incidence of coronary artery aneurysms if given before 7 days. However, in some, these lesions persist and require ongoing management during follow-up during childhood and into adult life. Evidence for further investigations in order to minimize complications is presented in order to minimize the myofibroblast proliferation and stenosis in the long term.

Original languageEnglish
Pages (from-to)491-501
Number of pages11
JournalFuture Cardiology
Volume13
Issue number5
Early online date22 Aug 2017
DOIs
Publication statusPublished - 1 Sep 2017

Keywords

  • Aneurysms
  • coronary artery
  • Kawasaki disease
  • vasculitis

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