Kawasaki disease: Diagnosis, management and cardiac sequelae

Louise Wood, Robert Tulloh*

*Corresponding author for this work

    Research output: Contribution to journalReview article (Academic Journal)peer-review

    14 Citations (Scopus)

    Abstract

    Kawasaki disease (KD) is an acute self-limiting systemic vasculitis of unknown etiology and the most common cause of acquired coronary disease in children aged 6 months to 5 years. The inflammatory process results in coronary arteritis, aneurysmal lesions, arterial thrombotic occlusion or even sudden death. The diagnostic tests are unknown but treatment with immunoglobulin and aspirin is effective at reducing cardiac complications from 25 to 4.7% in the UK. Myocardial, endocardial or pericardial inflammation may occur acutely or many years later and abnormalities of myocardial blood flow may require ongoing medication, interventional catheterization or even cardiac surgery. There are several new drugs that may have important roles to play in managing KD in children and young adults.

    Original languageEnglish
    Pages (from-to)553-561
    Number of pages9
    JournalExpert Review of Cardiovascular Therapy
    Volume5
    Issue number3
    DOIs
    Publication statusPublished - 1 May 2007

    Keywords

    • Aspirin
    • Coronary aneurysms
    • Endothelial dysfunction
    • Immunoglobulin
    • Myocardial blood flow
    • Myocardial ischemia
    • Vasculitis

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