Kinetic characterization of VIM-7, a divergent member of the VIM metallo-beta-lactamase family

O Samuelsen, M Castanheira, TR Walsh, J Spencer

Research output: Contribution to journalArticle (Academic Journal)

25 Citations (Scopus)

Abstract

Purified recombinant VIM-7 possesses efficient penicillinase and carbapenemase activities comparable to those of VIM-2. Cephalosporinase activity was variable and generally lower than those of VIM-1 and VIM-2. A homology model suggests that the VIM-7 Tyr-218 Phe substitution may be responsible for the reduced catalytic efficiency against certain cephalosporins, including ceftazidime and cefepime.
Original languageEnglish
Pages (from-to)2905 - 2908
Number of pages4
JournalAntimicrobial Agents and Chemotherapy
Volume52
Issue number8
DOIs
Publication statusPublished - Aug 2008

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