Kinetic characterization of VIM-7, a divergent member of the VIM metallo-beta-lactamase family

O Samuelsen; M Castanheira; TR Walsh; J Spencer

doi:10.1128/AAC.00166-08

Kinetic characterization of VIM-7, a divergent member of the VIM metallo-beta-lactamase family

O Samuelsen, M Castanheira, TR Walsh, J Spencer

School of Cellular and Molecular Medicine

Research output: Contribution to journal › Article (Academic Journal) › peer-review

28 Citations (Scopus)

Abstract

Purified recombinant VIM-7 possesses efficient penicillinase and carbapenemase activities comparable to those of VIM-2. Cephalosporinase activity was variable and generally lower than those of VIM-1 and VIM-2. A homology model suggests that the VIM-7 Tyr-218 Phe substitution may be responsible for the reduced catalytic efficiency against certain cephalosporins, including ceftazidime and cefepime.

Translated title of the contribution	Kinetic characterization of VIM-7, a divergent member of the VIM metallo-beta-lactamase family
Original language	English
Pages (from-to)	2905 - 2908
Number of pages	4
Journal	Antimicrobial Agents and Chemotherapy
Volume	52
Issue number	8
DOIs	https://doi.org/10.1128/AAC.00166-08
Publication status	Published - Aug 2008

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abstract = "Purified recombinant VIM-7 possesses efficient penicillinase and carbapenemase activities comparable to those of VIM-2. Cephalosporinase activity was variable and generally lower than those of VIM-1 and VIM-2. A homology model suggests that the VIM-7 Tyr-218 Phe substitution may be responsible for the reduced catalytic efficiency against certain cephalosporins, including ceftazidime and cefepime.",

author = "O Samuelsen and M Castanheira and TR Walsh and J Spencer",

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AU - Castanheira, M

AU - Walsh, TR

AU - Spencer, J

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AB - Purified recombinant VIM-7 possesses efficient penicillinase and carbapenemase activities comparable to those of VIM-2. Cephalosporinase activity was variable and generally lower than those of VIM-1 and VIM-2. A homology model suggests that the VIM-7 Tyr-218 Phe substitution may be responsible for the reduced catalytic efficiency against certain cephalosporins, including ceftazidime and cefepime.

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JO - Antimicrobial Agents and Chemotherapy

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ER -

Kinetic characterization of VIM-7, a divergent member of the VIM metallo-beta-lactamase family

Abstract

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