Knowledge Gaps in Oncoplastic Breast Surgery

Walter Weber*, Monica Morrow, Jana de Boniface, Andrea Pusic, Giacomo Montagna, Elisabeth A Kappos, Mathilde Ritter, Ramon Saccilotto, Alexandra Schulz, John Benson, Florian Fitzal, Zoltan Matrai, Jane Shaw, Marie-Jeanne Vrancken-Peeters, Shelley Potter, Joerg Heil, Oncoplastic Breast Consortium

*Corresponding author for this work

Research output: Contribution to journalArticle (Academic Journal)

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The aims of the Oncoplastic Breast Consortium initiative were to identify important knowledge gaps in the field of oncoplastic breast-conserving surgery and nipple-sparing or skin-sparing mastectomy with immediate breast reconstruction, and to recommend appropriate research strategies to address these gaps. A total of 212 surgeons and 26 patient advocates from 55 countries prioritised the 15 most important knowledge gaps from a list of 38 in two electronic Delphi rounds. An interdisciplinary panel of the Oncoplastic Breast Consortium consisting of 63 stakeholders from 20 countries obtained consensus during an in-person meeting to select seven of these 15 knowledge gaps as research priorities. Three key recommendations emerged from the meeting. First, the effect of oncoplastic breast-conserving surgery on quality of life and the optimal type and timing of reconstruction after nipple-sparing or skin-sparing mastectomy with planned radiotherapy should be addressed by prospective cohort studies at an international level. Second, the role of adjunctive mesh and the positioning of implants during implant-based breast reconstruction should ideally be investigated by randomised controlled trials of pragmatic design. Finally, the BREAST-Q questionnaire is a suitable tool to assess primary outcomes in these studies, but other metrics to measure patient-reported outcomes should be systematically evaluated and quality indicators of surgical morbidity should be further assessed.
Original languageEnglish
Pages (from-to)e375-e385
Number of pages11
JournalThe Lancet Oncology
Issue number8
Publication statusPublished - 3 Aug 2020

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    Weber, W., Morrow, M., de Boniface, J., Pusic, A., Montagna, G., Kappos, E. A., Ritter, M., Saccilotto, R., Schulz, A., Benson, J., Fitzal, F., Matrai, Z., Shaw, J., Vrancken-Peeters, M-J., Potter, S., Heil, J., & Oncoplastic Breast Consortium (2020). Knowledge Gaps in Oncoplastic Breast Surgery. The Lancet Oncology, 21(8), e375-e385.