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Label-invariant models for the analysis of meta-epidemiological data

Research output: Contribution to journalArticle

Original languageEnglish
Article number7491
Pages (from-to)60-70
Number of pages11
JournalStatistics in Medicine
Volume37
Issue number1
Early online date19 Sep 2017
DOIs
DateSubmitted - 1 Apr 2017
DateAccepted/In press - 20 Aug 2017
DateE-pub ahead of print - 19 Sep 2017
DatePublished (current) - 15 Jan 2018

Abstract

Rich meta-epidemiological data sets have been collected to explore associations between intervention effect estimates and study-level characteristics. Welton et al proposed models for the analysis of meta-epidemiological data, but these models are restrictive because they force heterogeneity among studies with a particular characteristic to be at least as large as that among studies without the characteristic. In this paper we present alternative models that are invariant to the labels defining the 2 categories of studies. To exemplify the methods, we use a collection of meta-analyses in which the Cochrane Risk of Bias tool has been implemented. We first investigate the influence of small trial sample sizes (less than 100 participants), before investigating the influence of multiple methodological flaws (inadequate or unclear sequence generation, allocation concealment, and blinding). We fit both the Welton et al model and our proposed label-invariant model and compare the results. Estimates of mean bias associated with the trial characteristics and of between-trial variances are not very sensitive to the choice of model. Results from fitting a univariable model show that heterogeneity variance is, on average, 88% greater among trials with less than 100 participants. On the basis of a multivariable model, heterogeneity variance is, on average, 25% greater among trials with inadequate/unclear sequence generation, 51% greater among trials with inadequate/unclear blinding, and 23% lower among trials with inadequate/unclear allocation concealment, although the 95% intervals for these ratios are very wide. Our proposed label-invariant models for meta-epidemiological data analysis facilitate investigations of between-study heterogeneity attributable to certain study characteristics.

    Research areas

  • Bayesian methods, Cochrane, heterogeneity, meta-epidemiology, randomised trials

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    Rights statement: This is the final published version of the article (version of record). It first appeared online via Wiley at http://onlinelibrary.wiley.com/doi/10.1002/sim.7491/abstract. Please refer to any applicable terms of use of the publisher.

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    Rights statement: This is the final published version of the article (version of record). It first appeared online via Wiley at http://onlinelibrary.wiley.com/doi/10.1002/sim.7491/abstract . Please refer to any applicable terms of use of the publisher.

    Final published version, 276 KB, PDF document

    Licence: CC BY

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