Lack of the murine homeobox gene Hesx1 leads to a posterior transformation of the anterior forebrain

Cynthia L Andoniadou, Massimo Signore, Ezat Sajedi, Carles Gaston-Massuet, Daniel Kelberman, Alan J Burns, Nobue Itasaki, Mehul Dattani, Juan Pedro Martinez-Barbera

Research output: Contribution to journalArticle (Academic Journal)peer-review

58 Citations (Scopus)
269 Downloads (Pure)

Abstract

The homeobox gene Hesx1 is an essential repressor that is required within the anterior neural plate for normal forebrain development in mouse and humans. Combining genetic cell labelling and marker analyses, we demonstrate that the absence of Hesx1 leads to a posterior transformation of the anterior forebrain (AFB) during mouse development. Our data suggest that the mechanism underlying this transformation is the ectopic activation of Wnt/beta-catenin signalling within the Hesx1 expression domain in the AFB. When ectopically expressed in the developing mouse embryo, Hesx1 alone cannot alter the normal fate of posterior neural tissue. However, conditional expression of Hesx1 within the AFB can rescue the forebrain defects observed in the Hesx1 mutants. The results presented here provide new insights into the function of Hesx1 in forebrain formation.

Original languageEnglish
Pages (from-to)1499-1508
Number of pages10
JournalDevelopment (Cambridge)
Volume134
Issue number8
Early online date14 Mar 2007
DOIs
Publication statusPublished - Apr 2007

Keywords

  • Animals
  • Axin Protein
  • Cell Differentiation
  • Cell Line
  • Cell Lineage
  • Cytoskeletal Proteins
  • Eye Proteins
  • Homeodomain Proteins
  • Mice
  • Mice, Knockout
  • Mutation
  • Nerve Tissue Proteins
  • Prosencephalon
  • Repressor Proteins
  • Transcription Factors
  • Wnt1 Protein
  • beta Catenin

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