Lactose as a "trojan horse" for quantum dot cell transport

David Benito-Alifonso, Shirley Tremel, Bo Hou, Harriet Lockyear, Judith Mantell, David J Fermin, Paul Verkade, Monica Berry*, M Carmen Galan

*Corresponding author for this work

Research output: Contribution to journalArticle (Academic Journal)peer-review

42 Citations (Scopus)

Abstract

A series of glycan-coated quantum dots were prepared to probe the effect of glycan presentation in intracellular localization in HeLa and SV40 epithelial cells. We show that glycan density mostly impacts on cell toxicity, whereas glycan type affects the cell uptake and intracellular localization. Moreover, we show that lactose can act as a "Trojan horse" on bi-functionalized QDs to help intracellular delivery of other non-internalizable glycan moieties and largely avoid the endosomal/lysosomal degradative pathway.
Original languageEnglish
Pages (from-to)810-814
Number of pages5
JournalAngewandte Chemie - International Edition
Volume53
Issue number3
DOIs
Publication statusPublished - 13 Jan 2014

Bibliographical note

Copyright © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Keywords

  • glycans
  • intracellular localization
  • multivalency
  • nanoparticles
  • quantum dots
  • GOLD NANOPARTICLES
  • PROTEIN
  • ENDOCYTOSIS
  • GLYCONANOPARTICLES
  • GLYCOBIOLOGY
  • NANOSCALE
  • MEDICINE
  • LIGANDS
  • BIOLOGY
  • FATE

Fingerprint Dive into the research topics of 'Lactose as a "trojan horse" for quantum dot cell transport'. Together they form a unique fingerprint.

Cite this