Lamotrigine ethanol monosolvate

Research output: Contribution to journalArticle (Academic Journal)peer-review

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Abstract

Lamotrigine is an active pharmaceutical ingredient used as a treatment for epilepsy and psychiatric disorders. Single crystals of an ethanolate solvate, C9 H7 Cl2 N 5·C2 H5 OH, were produced by slow evaporation of a saturated solution from anhydrous ethanol. Within the crystal structure, the lamotrigine molecules form dimers through N - H...N hydrogen bonds involving the amine N atoms in the ortho position of the triazine group. These dimers are linked into a tape motif through hydrogen bonds involving the amine N atoms in the para position. The ethanol and lamotrigine are present in a 1:1 ratio in the lattice with the ethyl group of the ethanol molecule exhibiting disorder with an occupancy ratio of 0.516 (14):0.484 (14).

Original languageEnglish
Pages (from-to)678-681
Number of pages4
JournalActa Crystallographica Section E: Crystallographic Communications
Volume74
Early online date19 Apr 2018
DOIs
Publication statusPublished - May 2018

Keywords

  • crystal structure
  • ethanolate
  • lamotrigine

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