Lamotrigine ethanol monosolvate

Charlie L. Hall; Jason Potticary; Hazel A. Sparkes; Natalie E. Pridmore; Simon R. Hall

doi:10.1107/S2056989018005819

Lamotrigine ethanol monosolvate

Charlie L. Hall, Jason Potticary, Hazel A. Sparkes, Natalie E. Pridmore, Simon R. Hall^*

^*Corresponding author for this work

Research output: Contribution to journal › Article (Academic Journal) › peer-review

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Abstract

Lamotrigine is an active pharmaceutical ingredient used as a treatment for epilepsy and psychiatric disorders. Single crystals of an ethanolate solvate, C₉ H₇ Cl₂ N 5·C₂ H₅ OH, were produced by slow evaporation of a saturated solution from anhydrous ethanol. Within the crystal structure, the lamotrigine molecules form dimers through N - H...N hydrogen bonds involving the amine N atoms in the ortho position of the triazine group. These dimers are linked into a tape motif through hydrogen bonds involving the amine N atoms in the para position. The ethanol and lamotrigine are present in a 1:1 ratio in the lattice with the ethyl group of the ethanol molecule exhibiting disorder with an occupancy ratio of 0.516 (14):0.484 (14).

Original language	English
Pages (from-to)	678-681
Number of pages	4
Journal	Acta Crystallographica Section E: Crystallographic Communications
Volume	74
Early online date	19 Apr 2018
DOIs	https://doi.org/10.1107/S2056989018005819
Publication status	Published - May 2018

Keywords

crystal structure
ethanolate
lamotrigine

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title = "Lamotrigine ethanol monosolvate",

abstract = "Lamotrigine is an active pharmaceutical ingredient used as a treatment for epilepsy and psychiatric disorders. Single crystals of an ethanolate solvate, C9 H7 Cl2 N 5·C2 H5 OH, were produced by slow evaporation of a saturated solution from anhydrous ethanol. Within the crystal structure, the lamotrigine molecules form dimers through N - H...N hydrogen bonds involving the amine N atoms in the ortho position of the triazine group. These dimers are linked into a tape motif through hydrogen bonds involving the amine N atoms in the para position. The ethanol and lamotrigine are present in a 1:1 ratio in the lattice with the ethyl group of the ethanol molecule exhibiting disorder with an occupancy ratio of 0.516 (14):0.484 (14).",

keywords = "crystal structure, ethanolate, lamotrigine",

author = "Hall, {Charlie L.} and Jason Potticary and Sparkes, {Hazel A.} and Pridmore, {Natalie E.} and Hall, {Simon R.}",

year = "2018",

month = may,

doi = "10.1107/S2056989018005819",

language = "English",

volume = "74",

pages = "678--681",

journal = "Acta Crystallographica Section E: Crystallographic Communications",

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publisher = "John Wiley & Sons, Ltd.",

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TY - JOUR

T1 - Lamotrigine ethanol monosolvate

AU - Hall, Charlie L.

AU - Potticary, Jason

AU - Sparkes, Hazel A.

AU - Pridmore, Natalie E.

AU - Hall, Simon R.

PY - 2018/5

Y1 - 2018/5

N2 - Lamotrigine is an active pharmaceutical ingredient used as a treatment for epilepsy and psychiatric disorders. Single crystals of an ethanolate solvate, C9 H7 Cl2 N 5·C2 H5 OH, were produced by slow evaporation of a saturated solution from anhydrous ethanol. Within the crystal structure, the lamotrigine molecules form dimers through N - H...N hydrogen bonds involving the amine N atoms in the ortho position of the triazine group. These dimers are linked into a tape motif through hydrogen bonds involving the amine N atoms in the para position. The ethanol and lamotrigine are present in a 1:1 ratio in the lattice with the ethyl group of the ethanol molecule exhibiting disorder with an occupancy ratio of 0.516 (14):0.484 (14).

AB - Lamotrigine is an active pharmaceutical ingredient used as a treatment for epilepsy and psychiatric disorders. Single crystals of an ethanolate solvate, C9 H7 Cl2 N 5·C2 H5 OH, were produced by slow evaporation of a saturated solution from anhydrous ethanol. Within the crystal structure, the lamotrigine molecules form dimers through N - H...N hydrogen bonds involving the amine N atoms in the ortho position of the triazine group. These dimers are linked into a tape motif through hydrogen bonds involving the amine N atoms in the para position. The ethanol and lamotrigine are present in a 1:1 ratio in the lattice with the ethyl group of the ethanol molecule exhibiting disorder with an occupancy ratio of 0.516 (14):0.484 (14).

KW - crystal structure

KW - ethanolate

KW - lamotrigine

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U2 - 10.1107/S2056989018005819

DO - 10.1107/S2056989018005819

M3 - Article (Academic Journal)

C2 - 29850090

AN - SCOPUS:85046758697

SN - 2056-9890

VL - 74

SP - 678

EP - 681

JO - Acta Crystallographica Section E: Crystallographic Communications

JF - Acta Crystallographica Section E: Crystallographic Communications

ER -

Lamotrigine ethanol monosolvate

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