Laser-induced convection shifts size distributions in Nanoparticle Tracking Analysis

Wil H Hoffmann; Niall Mulkerns; Simon R Hall; Henkjan Gersen

doi:10.1039/d1na00572c

Laser-induced convection shifts size distributions in Nanoparticle Tracking Analysis

Wil H Hoffmann, Niall Mulkerns, Simon R Hall, Henkjan Gersen^*

^*Corresponding author for this work

Research output: Contribution to journal › Article (Academic Journal) › peer-review

3 Citations (Scopus)

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Abstract

This work discusses the effects of increasing laser power on the size data derived from NTA for particles of known size and scatterers in solutions of flufenamic acid in ethanol. We find that whilst a higher laser power reveals more particles as expected, their residence time changes due to laser-induced convection. This reduced residence time decreases the number of tracks available for individual particle size determination, shifting the size distribution to smaller values. This problem is overcome by using a shutter to inhibit the development of convection currents, increasing particle residence time and reducing the error on the size distribution. The detailed understanding of laser-induced convection permits more robust size characterisation of mesoscopic organic clusters, which play a key role in two-step nucleation theory.

Original language	English
Pages (from-to)	5694 - 5702
Number of pages	9
Journal	Nanoscale Advances
Volume	3
Issue number	19
Early online date	1 Sept 2021
DOIs	https://doi.org/10.1039/d1na00572c
Publication status	Published - 7 Oct 2021

Bibliographical note

Funding Information:
W. H. H., S. R. H., and H. G. acknowledge the Engineering and Physical Sciences Research Council (EPSRC) for funding under grant number EP/L016648/1. W. H. H. and S. R. H. acknowledge support by MagnaPharm, a European Union Horizon 2020 Research and Innovation programme under grant agreement number 736899. N. M. and H. G. acknowledge support from an EPSRC National Productivity Investment Fund cofunded by Carbometrics under grant number EP/R51245/X. W. H. H. thanks Adrian Crimp and his team at the University of Bristol Mechanical Workshop for machining components of the device.

Publisher Copyright:
© The Royal Society of Chemistry.

Research Groups and Themes

Inorganic & Materials

Keywords

Nanoparticle detection
Brownian motion
convection
light scattering
mesoscopic cluster
nanoparticle tracking analysis

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3 Citations
1 Article (Academic Journal)

Determining Nanorod Dimensions in Dispersion with Size Anisotropy Nanoparticle Tracking Analysis
Hoffmann, W. H., Gao, B., Mulkerns, N., Hinton, A. G., Hanna, S., Hall, S. R. & Gersen, H., 18 May 2022, In: Physical Chemistry Chemical Physics. 24, 21, p. 13040-13048 9 p.
Research output: Contribution to journal › Article (Academic Journal) › peer-review

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2 Citations (Scopus)

133 Downloads (Pure)

Cite this

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title = "Laser-induced convection shifts size distributions in Nanoparticle Tracking Analysis",

abstract = "This work discusses the effects of increasing laser power on the size data derived from NTA for particles of known size and scatterers in solutions of flufenamic acid in ethanol. We find that whilst a higher laser power reveals more particles as expected, their residence time changes due to laser-induced convection. This reduced residence time decreases the number of tracks available for individual particle size determination, shifting the size distribution to smaller values. This problem is overcome by using a shutter to inhibit the development of convection currents, increasing particle residence time and reducing the error on the size distribution. The detailed understanding of laser-induced convection permits more robust size characterisation of mesoscopic organic clusters, which play a key role in two-step nucleation theory.",

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note = "Funding Information: W. H. H., S. R. H., and H. G. acknowledge the Engineering and Physical Sciences Research Council (EPSRC) for funding under grant number EP/L016648/1. W. H. H. and S. R. H. acknowledge support by MagnaPharm, a European Union Horizon 2020 Research and Innovation programme under grant agreement number 736899. N. M. and H. G. acknowledge support from an EPSRC National Productivity Investment Fund cofunded by Carbometrics under grant number EP/R51245/X. W. H. H. thanks Adrian Crimp and his team at the University of Bristol Mechanical Workshop for machining components of the device. Publisher Copyright: {\textcopyright} The Royal Society of Chemistry.",

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PY - 2021/10/7

Y1 - 2021/10/7

N2 - This work discusses the effects of increasing laser power on the size data derived from NTA for particles of known size and scatterers in solutions of flufenamic acid in ethanol. We find that whilst a higher laser power reveals more particles as expected, their residence time changes due to laser-induced convection. This reduced residence time decreases the number of tracks available for individual particle size determination, shifting the size distribution to smaller values. This problem is overcome by using a shutter to inhibit the development of convection currents, increasing particle residence time and reducing the error on the size distribution. The detailed understanding of laser-induced convection permits more robust size characterisation of mesoscopic organic clusters, which play a key role in two-step nucleation theory.

AB - This work discusses the effects of increasing laser power on the size data derived from NTA for particles of known size and scatterers in solutions of flufenamic acid in ethanol. We find that whilst a higher laser power reveals more particles as expected, their residence time changes due to laser-induced convection. This reduced residence time decreases the number of tracks available for individual particle size determination, shifting the size distribution to smaller values. This problem is overcome by using a shutter to inhibit the development of convection currents, increasing particle residence time and reducing the error on the size distribution. The detailed understanding of laser-induced convection permits more robust size characterisation of mesoscopic organic clusters, which play a key role in two-step nucleation theory.

KW - Nanoparticle detection

KW - Brownian motion

KW - convection

KW - light scattering

KW - mesoscopic cluster

KW - nanoparticle tracking analysis

U2 - 10.1039/d1na00572c

DO - 10.1039/d1na00572c

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JO - Nanoscale Advances

JF - Nanoscale Advances

IS - 19

ER -

Laser-induced convection shifts size distributions in Nanoparticle Tracking Analysis

Abstract

Bibliographical note

Research Groups and Themes

Keywords

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Research output

Determining Nanorod Dimensions in Dispersion with Size Anisotropy Nanoparticle Tracking Analysis

Cite this