LDL-cholesterol concentrations: a genome-wide association study

Manjinder S Sandhu; Dawn M Waterworth; Sally L Debenham; Eleanor Wheeler; Konstantinos Papadakis; Jing Hua Zhao; Kijoung Song; Xin Yuan; Toby Johnson; Sofie Ashford; Michael Inouye; Robert Luben; Matthew Sims; David Hadley; Wendy McArdle; Philip Barter; Y Antero Kesäniemi; Robert W Mahley; Ruth McPherson; Scott M Grundy; Sheila A Bingham; Kay-Tee Khaw; Ruth J F Loos; Gérard Waeber; Inês Barroso; David P Strachan; Panagiotis Deloukas; Peter Vollenweider; Nicholas J Wareham; Vincent Mooser; Wellcome Trust Case Control Consortium

doi:10.1016/S0140-6736(08)60208-1

LDL-cholesterol concentrations: a genome-wide association study

Manjinder S Sandhu, Dawn M Waterworth, Sally L Debenham, Eleanor Wheeler, Konstantinos Papadakis, Jing Hua Zhao, Kijoung Song, Xin Yuan, Toby Johnson, Sofie Ashford, Michael Inouye, Robert Luben, Matthew Sims, David Hadley, Wendy McArdle, Philip Barter, Y Antero Kesäniemi, Robert W Mahley, Ruth McPherson, Scott M GrundySheila A Bingham, Kay-Tee Khaw, Ruth J F Loos, Gérard Waeber, Inês Barroso, David P Strachan, Panagiotis Deloukas, Peter Vollenweider, Nicholas J Wareham, Vincent Mooser, Wellcome Trust Case Control Consortium

Bristol Medical School (PHS)

Research output: Contribution to journal › Article (Academic Journal) › peer-review

284 Citations (Scopus)

Abstract

LDL cholesterol has a causal role in the development of cardiovascular disease. Improved understanding of the biological mechanisms that underlie the metabolism and regulation of LDL cholesterol might help to identify novel therapeutic targets. We therefore did a genome-wide association study of LDL-cholesterol concentrations.

Original language	English
Pages (from-to)	483-91
Number of pages	9
Journal	Lancet
Volume	371
Issue number	9611
DOIs	https://doi.org/10.1016/S0140-6736(08)60208-1
Publication status	Published - 2008

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Sandhu, M. S., Waterworth, D. M., Debenham, S. L., Wheeler, E., Papadakis, K., Zhao, J. H., Song, K., Yuan, X., Johnson, T., Ashford, S., Inouye, M., Luben, R., Sims, M., Hadley, D., McArdle, W., Barter, P., Kesäniemi, Y. A., Mahley, R. W., McPherson, R., ... Wellcome Trust Case Control Consortium (2008). LDL-cholesterol concentrations: a genome-wide association study. Lancet, 371(9611), 483-91. https://doi.org/10.1016/S0140-6736(08)60208-1

@article{ebf2e1725e564097abd1881ced538f78,

title = "LDL-cholesterol concentrations: a genome-wide association study",

abstract = "LDL cholesterol has a causal role in the development of cardiovascular disease. Improved understanding of the biological mechanisms that underlie the metabolism and regulation of LDL cholesterol might help to identify novel therapeutic targets. We therefore did a genome-wide association study of LDL-cholesterol concentrations.",

author = "Sandhu, {Manjinder S} and Waterworth, {Dawn M} and Debenham, {Sally L} and Eleanor Wheeler and Konstantinos Papadakis and Zhao, {Jing Hua} and Kijoung Song and Xin Yuan and Toby Johnson and Sofie Ashford and Michael Inouye and Robert Luben and Matthew Sims and David Hadley and Wendy McArdle and Philip Barter and Kes{\"a}niemi, {Y Antero} and Mahley, {Robert W} and Ruth McPherson and Grundy, {Scott M} and Bingham, {Sheila A} and Kay-Tee Khaw and Loos, {Ruth J F} and G{\'e}rard Waeber and In{\^e}s Barroso and Strachan, {David P} and Panagiotis Deloukas and Peter Vollenweider and Wareham, {Nicholas J} and Vincent Mooser and {Wellcome Trust Case Control Consortium}",

year = "2008",

doi = "10.1016/S0140-6736(08)60208-1",

language = "English",

volume = "371",

pages = "483--91",

journal = "Lancet",

issn = "0140-6736",

publisher = "Lancet Publishing Group",

number = "9611",

}

Sandhu, MS, Waterworth, DM, Debenham, SL, Wheeler, E, Papadakis, K, Zhao, JH, Song, K, Yuan, X, Johnson, T, Ashford, S, Inouye, M, Luben, R, Sims, M, Hadley, D, McArdle, W, Barter, P, Kesäniemi, YA, Mahley, RW, McPherson, R, Grundy, SM, Bingham, SA, Khaw, K-T, Loos, RJF, Waeber, G, Barroso, I, Strachan, DP, Deloukas, P, Vollenweider, P, Wareham, NJ, Mooser, V & Wellcome Trust Case Control Consortium 2008, 'LDL-cholesterol concentrations: a genome-wide association study', Lancet, vol. 371, no. 9611, pp. 483-91. https://doi.org/10.1016/S0140-6736(08)60208-1

TY - JOUR

T1 - LDL-cholesterol concentrations

T2 - a genome-wide association study

AU - Sandhu, Manjinder S

AU - Waterworth, Dawn M

AU - Debenham, Sally L

AU - Wheeler, Eleanor

AU - Papadakis, Konstantinos

AU - Zhao, Jing Hua

AU - Song, Kijoung

AU - Yuan, Xin

AU - Johnson, Toby

AU - Ashford, Sofie

AU - Inouye, Michael

AU - Luben, Robert

AU - Sims, Matthew

AU - Hadley, David

AU - McArdle, Wendy

AU - Barter, Philip

AU - Kesäniemi, Y Antero

AU - Mahley, Robert W

AU - McPherson, Ruth

AU - Grundy, Scott M

AU - Bingham, Sheila A

AU - Khaw, Kay-Tee

AU - Loos, Ruth J F

AU - Waeber, Gérard

AU - Barroso, Inês

AU - Strachan, David P

AU - Deloukas, Panagiotis

AU - Vollenweider, Peter

AU - Wareham, Nicholas J

AU - Mooser, Vincent

AU - Wellcome Trust Case Control Consortium

PY - 2008

Y1 - 2008

N2 - LDL cholesterol has a causal role in the development of cardiovascular disease. Improved understanding of the biological mechanisms that underlie the metabolism and regulation of LDL cholesterol might help to identify novel therapeutic targets. We therefore did a genome-wide association study of LDL-cholesterol concentrations.

AB - LDL cholesterol has a causal role in the development of cardiovascular disease. Improved understanding of the biological mechanisms that underlie the metabolism and regulation of LDL cholesterol might help to identify novel therapeutic targets. We therefore did a genome-wide association study of LDL-cholesterol concentrations.

U2 - 10.1016/S0140-6736(08)60208-1

DO - 10.1016/S0140-6736(08)60208-1

M3 - Article (Academic Journal)

C2 - 18262040

VL - 371

SP - 483

EP - 491

JO - Lancet

JF - Lancet

SN - 0140-6736

IS - 9611

ER -

LDL-cholesterol concentrations: a genome-wide association study

Abstract

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