LDL-cholesterol concentrations: a genome-wide association study

Manjinder S Sandhu, Dawn M Waterworth, Sally L Debenham, Eleanor Wheeler, Konstantinos Papadakis, Jing Hua Zhao, Kijoung Song, Xin Yuan, Toby Johnson, Sofie Ashford, Michael Inouye, Robert Luben, Matthew Sims, David Hadley, Wendy McArdle, Philip Barter, Y Antero Kesäniemi, Robert W Mahley, Ruth McPherson, Scott M GrundySheila A Bingham, Kay-Tee Khaw, Ruth J F Loos, Gérard Waeber, Inês Barroso, David P Strachan, Panagiotis Deloukas, Peter Vollenweider, Nicholas J Wareham, Vincent Mooser, Wellcome Trust Case Control Consortium

Research output: Contribution to journalArticle (Academic Journal)peer-review

265 Citations (Scopus)

Abstract

LDL cholesterol has a causal role in the development of cardiovascular disease. Improved understanding of the biological mechanisms that underlie the metabolism and regulation of LDL cholesterol might help to identify novel therapeutic targets. We therefore did a genome-wide association study of LDL-cholesterol concentrations.
Original languageEnglish
Pages (from-to)483-91
Number of pages9
JournalLancet
Volume371
Issue number9611
DOIs
Publication statusPublished - 2008

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