Leaf concentrate as an alternative to iron and folic acid supplements for anaemic adolescent girls: a randomised controlled trial in India

Vyas Swati, SM Collin, Bertin E, Davys Glyn, Mathur Beena

Research output: Contribution to journalArticle (Academic Journal)peer-review

16 Citations (Scopus)

Abstract

OBJECTIVE: Despite public health campaigns based on Fe and folic acid supplements, Fe-deficiency anaemia remains highly prevalent among women in India. We investigated leaf concentrate as an alternative to Fe and folic acid supplements for treating anaemia in adolescent girls. DESIGN: Randomised controlled two-arm trial over 3 months: one group received daily Fe and folic acid (IFA; 60 mg Fe, 500 mug folic acid); the other daily leaf concentrate (LC; 5 mg Fe, 13 mug folic acid). Hb concentration, mean cell volume, serum Fe, serum ferritin and total Fe-binding capacity were measured pre- and post-intervention. SETTING: Jaipur, India. SUBJECTS: One hundred and two adolescent girls aged 14-18 years. RESULTS: Of the 102 girls randomized to the two arms of the trial, four (3.9 %) were severely anaemic (Hb <7 g/dl), twenty-eight (27.5 %) were moderately anaemic (Hb >/= 7 g/dl, /= 10 g/dl, /=12 g/dl). After adjustment for baseline values, LC was as effective as IFA in improving serum Fe parameters and treating anaemia. CONCLUSIONS: Leaf concentrate is an effective, and more palatable, alternative to Fe and folic acid supplements for treating anaemia in adolescent girls.
Translated title of the contributionLeaf concentrate as an alternative to iron and folic acid supplements for anaemic adolescent girls: a randomised controlled trial in India
Original languageEnglish
Pages (from-to)418 - 423
Number of pages6
JournalPublic Health Nutrition
Volume13
DOIs
Publication statusPublished - Mar 2010

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