Left ventricular remodeling after transcatheter aortic valve implantation: one-year follow-up study

Mustafa Zakkar, Aiman Alassar, Manuel Lopez-Perez, David Roy, Stephen Brecker, Rajan Sharma, Marjan Jahangiri

Research output: Contribution to journalArticle (Academic Journal)peer-review

2 Citations (Scopus)


OBJECTIVE: The impact of transcatheter aortic valve implantation (TAVI) on left ventricular (LV) mass regression is not well defined. We aimed to measure LV mass regression, changes in LV volumes and dimensions, as well as mitral valve function after TAVI.

METHODS: Eighty patients who underwent TAVI between 2008 and 2010 were studied. Echocardiographic findings before procedure and at 6- and 12-month follow-up were analyzed.

RESULTS: Aortic valve area increased from 0.71 (0.27) cm before procedure to 1.89 (0.64) cm at 12 months (P < 0.001), which was associated with reduction in peak [80.79 (23) vs 16.9 (6.5) mm Hg, P < 0.001] and mean [47.65 (14.2) vs 8.77 (3.29) mm Hg, P < 0.001] gradients. At 1 year, there was a change in LV end-systolic volume [46.12 (36.6) to 48.96 (4.05) mL, P = 0.042] and LV mass [202.4 (92.2) to 183.6 (98.2) g, P = 0.04]. Left ventricular mass index regressed from 130.7 (28.9) to 122.1 (28.9) g/m (P = 0.01). Maximum wall thickness decreased from 1.28 (0.18) to 1.25 (0.17) cm (P < 0.001). There was no significant change in LV ejection fraction, LV end-systolic and end-diastolic diameters, as well as mitral valve regurgitation.

CONCLUSIONS: Transcatheter aortic valve implantation is associated with significant regression of LV hypertrophy at 1 year. However, this regression was not associated with changes in LV systolic and diastolic functions, size, or changes in mitral valve regurgitation.

Original languageEnglish
Pages (from-to)44-7
Number of pages4
JournalInnovations (Philadelphia, Pa.)
Issue number1
Publication statusPublished - 3 Feb 2015


  • Aged, 80 and over
  • Aortic Valve Stenosis
  • Echocardiography
  • Female
  • Follow-Up Studies
  • Humans
  • Hypertrophy, Left Ventricular
  • Male
  • Mitral Valve Insufficiency
  • Transcatheter Aortic Valve Replacement
  • Ventricular Dysfunction, Left
  • Ventricular Remodeling

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