Length of the QT interval: determinants and prognostic implications in a population-based prospective study of older men

Syed Mohammad Afzal Sohaib; Olia Papacosta; Richard W. Morris; Peter W. Macfarlane; Peter H. Whincup

doi:10.1016/j.jelectrocard.2008.01.010

Length of the QT interval: determinants and prognostic implications in a population-based prospective study of older men

Syed Mohammad Afzal Sohaib
, Olia Papacosta
, Richard W. Morris
, Peter W. Macfarlane
, Peter H. Whincup^*

^*Corresponding author for this work

Bristol Medical School (PHS)

Research output: Contribution to journal › Article (Academic Journal) › peer-review

50 Citations (Scopus)

Abstract

OBJECTIVE: We examined potential determinants and prognostic value of the corrected QT interval (QTc).

DESIGN: A total of 4252 British men aged 60 to 79 years had a resting 12-lead electrocardiogram. Potential determinants of the QTc were assessed using multivariable regression. Men were followed up for 7 years.

RESULTS: A 1 standard deviation increase in QTc (26 milliseconds) was associated with increased all-cause mortality (hazard ratio, 1.13; 95% confidence interval, 1.05-1.22). Longer QTc was associated with increasing age, preexisting coronary heart disease, and a range of drugs. Shorter QTc was present in diabetics and smokers. Corrected QT interval was related inversely with serum potassium and calcium and positively with serum urate, sodium, and systolic blood pressure. The relation of QTc to all-cause mortality was independent of adjustment for these factors.

CONCLUSIONS: Age, preexisting coronary heart disease, certain medications and biochemical factors, and diabetes are independently associated with QTc. Corrected QT interval is an independent predictor of all-cause mortality.

Original language	English
Pages (from-to)	704-710
Number of pages	7
Journal	Journal of Electrocardiology
Volume	41
Issue number	6
DOIs	https://doi.org/10.1016/j.jelectrocard.2008.01.010
Publication status	Published - 28 Mar 2008

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SDG 3 Good Health and Well-being

Keywords

Adult
Electrocardiography
Great Britain
Heart Rate
Humans
Incidence
Long QT Syndrome
Male
Middle Aged
Prognosis
Prospective Studies
Reproducibility of Results
Risk Assessment
Risk Factors
Sensitivity and Specificity
Survival Analysis
Survival Rate

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@article{8d4576d4e89f4fedac644513a21f8a5d,

title = "Length of the QT interval: determinants and prognostic implications in a population-based prospective study of older men",

abstract = "OBJECTIVE: We examined potential determinants and prognostic value of the corrected QT interval (QTc).DESIGN: A total of 4252 British men aged 60 to 79 years had a resting 12-lead electrocardiogram. Potential determinants of the QTc were assessed using multivariable regression. Men were followed up for 7 years.RESULTS: A 1 standard deviation increase in QTc (26 milliseconds) was associated with increased all-cause mortality (hazard ratio, 1.13; 95\% confidence interval, 1.05-1.22). Longer QTc was associated with increasing age, preexisting coronary heart disease, and a range of drugs. Shorter QTc was present in diabetics and smokers. Corrected QT interval was related inversely with serum potassium and calcium and positively with serum urate, sodium, and systolic blood pressure. The relation of QTc to all-cause mortality was independent of adjustment for these factors.CONCLUSIONS: Age, preexisting coronary heart disease, certain medications and biochemical factors, and diabetes are independently associated with QTc. Corrected QT interval is an independent predictor of all-cause mortality.",

keywords = "Adult, Electrocardiography, Great Britain, Heart Rate, Humans, Incidence, Long QT Syndrome, Male, Middle Aged, Prognosis, Prospective Studies, Reproducibility of Results, Risk Assessment, Risk Factors, Sensitivity and Specificity, Survival Analysis, Survival Rate",

author = "Sohaib, \{Syed Mohammad Afzal\} and Olia Papacosta and Morris, \{Richard W.\} and Macfarlane, \{Peter W.\} and Whincup, \{Peter H.\}",

year = "2008",

month = mar,

day = "28",

doi = "10.1016/j.jelectrocard.2008.01.010",

language = "English",

volume = "41",

pages = "704--710",

journal = "Journal of Electrocardiology",

issn = "0022-0736",

publisher = "Elsevier B.V.",

number = "6",

}

TY - JOUR

T1 - Length of the QT interval

T2 - determinants and prognostic implications in a population-based prospective study of older men

AU - Sohaib, Syed Mohammad Afzal

AU - Papacosta, Olia

AU - Morris, Richard W.

AU - Macfarlane, Peter W.

AU - Whincup, Peter H.

PY - 2008/3/28

Y1 - 2008/3/28

N2 - OBJECTIVE: We examined potential determinants and prognostic value of the corrected QT interval (QTc).DESIGN: A total of 4252 British men aged 60 to 79 years had a resting 12-lead electrocardiogram. Potential determinants of the QTc were assessed using multivariable regression. Men were followed up for 7 years.RESULTS: A 1 standard deviation increase in QTc (26 milliseconds) was associated with increased all-cause mortality (hazard ratio, 1.13; 95% confidence interval, 1.05-1.22). Longer QTc was associated with increasing age, preexisting coronary heart disease, and a range of drugs. Shorter QTc was present in diabetics and smokers. Corrected QT interval was related inversely with serum potassium and calcium and positively with serum urate, sodium, and systolic blood pressure. The relation of QTc to all-cause mortality was independent of adjustment for these factors.CONCLUSIONS: Age, preexisting coronary heart disease, certain medications and biochemical factors, and diabetes are independently associated with QTc. Corrected QT interval is an independent predictor of all-cause mortality.

AB - OBJECTIVE: We examined potential determinants and prognostic value of the corrected QT interval (QTc).DESIGN: A total of 4252 British men aged 60 to 79 years had a resting 12-lead electrocardiogram. Potential determinants of the QTc were assessed using multivariable regression. Men were followed up for 7 years.RESULTS: A 1 standard deviation increase in QTc (26 milliseconds) was associated with increased all-cause mortality (hazard ratio, 1.13; 95% confidence interval, 1.05-1.22). Longer QTc was associated with increasing age, preexisting coronary heart disease, and a range of drugs. Shorter QTc was present in diabetics and smokers. Corrected QT interval was related inversely with serum potassium and calcium and positively with serum urate, sodium, and systolic blood pressure. The relation of QTc to all-cause mortality was independent of adjustment for these factors.CONCLUSIONS: Age, preexisting coronary heart disease, certain medications and biochemical factors, and diabetes are independently associated with QTc. Corrected QT interval is an independent predictor of all-cause mortality.

KW - Adult

KW - Electrocardiography

KW - Great Britain

KW - Heart Rate

KW - Humans

KW - Incidence

KW - Long QT Syndrome

KW - Male

KW - Middle Aged

KW - Prognosis

KW - Prospective Studies

KW - Reproducibility of Results

KW - Risk Assessment

KW - Risk Factors

KW - Sensitivity and Specificity

KW - Survival Analysis

KW - Survival Rate

U2 - 10.1016/j.jelectrocard.2008.01.010

DO - 10.1016/j.jelectrocard.2008.01.010

M3 - Article (Academic Journal)

C2 - 18367203

SN - 0022-0736

VL - 41

SP - 704

EP - 710

JO - Journal of Electrocardiology

JF - Journal of Electrocardiology

IS - 6

ER -

Length of the QT interval: determinants and prognostic implications in a population-based prospective study of older men

Abstract

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